Cargando…
The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence
PURPOSE: A review of the role of the carotenoids, lutein and zeaxanthin, and their function in altering the pathogenesis of age-related macular degeneration (AMD). METHODS: Medline and Embase search. RESULTS: Recent evidence introduces the possibility that lutein and zeaxanthin, carotenoids found in...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2003
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305368/ https://www.ncbi.nlm.nih.gov/pubmed/14670087 http://dx.doi.org/10.1186/1475-2891-2-20 |
_version_ | 1782121104075128832 |
---|---|
author | Mozaffarieh, Maneli Sacu, Stefan Wedrich, Andreas |
author_facet | Mozaffarieh, Maneli Sacu, Stefan Wedrich, Andreas |
author_sort | Mozaffarieh, Maneli |
collection | PubMed |
description | PURPOSE: A review of the role of the carotenoids, lutein and zeaxanthin, and their function in altering the pathogenesis of age-related macular degeneration (AMD). METHODS: Medline and Embase search. RESULTS: Recent evidence introduces the possibility that lutein and zeaxanthin, carotenoids found in a variety of fruits and vegetables may protect against the common eye disease of macular degeneration. This potential and the lack to slow the progression of macular degeneration, has fueled high public interest in the health benefits of these carotenoids and prompted their inclusion in various supplements. The body of evidence supporting a role in this disease ranges from basic studies in experimental animals to various other clinical and epidemiological studies. Whilst some epidemiological studies suggest a beneficial role for carotenoids in the prevention of AMD, others are found to be unrelated to it. Results of some clinical studies indicate that the risk for AMD is reduced when levels of the carotenoids are elevated in the serum or diet, but this correlation is not observed in other studies. Published data concerning the toxicity of the carotenoids or the optimum dosage of these supplements is lacking. CONCLUSION: An intake of dietary supplied nutrients rich in the carotenoids, lutein and zeaxanthin, appears to be beneficial in protecting retinal tissues, but this is not proven. Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to: alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors. Future investigations on the role of nutrition, light exposure, genetics, and combinations of photodynamic therapy with intravitreal steroid (triamcinolone-acetonide) injections hold potential for future treatment possibilities. |
format | Text |
id | pubmed-305368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3053682004-01-01 The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence Mozaffarieh, Maneli Sacu, Stefan Wedrich, Andreas Nutr J Review PURPOSE: A review of the role of the carotenoids, lutein and zeaxanthin, and their function in altering the pathogenesis of age-related macular degeneration (AMD). METHODS: Medline and Embase search. RESULTS: Recent evidence introduces the possibility that lutein and zeaxanthin, carotenoids found in a variety of fruits and vegetables may protect against the common eye disease of macular degeneration. This potential and the lack to slow the progression of macular degeneration, has fueled high public interest in the health benefits of these carotenoids and prompted their inclusion in various supplements. The body of evidence supporting a role in this disease ranges from basic studies in experimental animals to various other clinical and epidemiological studies. Whilst some epidemiological studies suggest a beneficial role for carotenoids in the prevention of AMD, others are found to be unrelated to it. Results of some clinical studies indicate that the risk for AMD is reduced when levels of the carotenoids are elevated in the serum or diet, but this correlation is not observed in other studies. Published data concerning the toxicity of the carotenoids or the optimum dosage of these supplements is lacking. CONCLUSION: An intake of dietary supplied nutrients rich in the carotenoids, lutein and zeaxanthin, appears to be beneficial in protecting retinal tissues, but this is not proven. Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to: alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors. Future investigations on the role of nutrition, light exposure, genetics, and combinations of photodynamic therapy with intravitreal steroid (triamcinolone-acetonide) injections hold potential for future treatment possibilities. BioMed Central 2003-12-11 /pmc/articles/PMC305368/ /pubmed/14670087 http://dx.doi.org/10.1186/1475-2891-2-20 Text en Copyright © 2003 Mozaffarieh et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Mozaffarieh, Maneli Sacu, Stefan Wedrich, Andreas The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title | The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title_full | The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title_fullStr | The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title_full_unstemmed | The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title_short | The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence |
title_sort | role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: a review based on controversial evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305368/ https://www.ncbi.nlm.nih.gov/pubmed/14670087 http://dx.doi.org/10.1186/1475-2891-2-20 |
work_keys_str_mv | AT mozaffariehmaneli theroleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence AT sacustefan theroleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence AT wedrichandreas theroleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence AT mozaffariehmaneli roleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence AT sacustefan roleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence AT wedrichandreas roleofthecarotenoidsluteinandzeaxanthininprotectingagainstagerelatedmaculardegenerationareviewbasedoncontroversialevidence |