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Acute leukemias with unusual immunophenotypes.

Over a two-year period, immunophenotypic patterns of 266 acute leukemia cases were analyzed using a panel of tests including TdT, SmIg and 9 surface antigens by the immunofluorescence stains for the assessment of the incidence and grade of phenotypic ambiguity (lineage infidelity) and the possible c...

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Autores principales: Park, M. H., Yang, Y. S., Cho, H. I., Kim, B. K., Park, S., Ahn, H. S., Shin, H. Y., Kang, H. J., Oh, W. I., Kim, S. I.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053839/
https://www.ncbi.nlm.nih.gov/pubmed/1299244
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author Park, M. H.
Yang, Y. S.
Cho, H. I.
Kim, B. K.
Park, S.
Ahn, H. S.
Shin, H. Y.
Kang, H. J.
Oh, W. I.
Kim, S. I.
author_facet Park, M. H.
Yang, Y. S.
Cho, H. I.
Kim, B. K.
Park, S.
Ahn, H. S.
Shin, H. Y.
Kang, H. J.
Oh, W. I.
Kim, S. I.
author_sort Park, M. H.
collection PubMed
description Over a two-year period, immunophenotypic patterns of 266 acute leukemia cases were analyzed using a panel of tests including TdT, SmIg and 9 surface antigens by the immunofluorescence stains for the assessment of the incidence and grade of phenotypic ambiguity (lineage infidelity) and the possible clinical significance of unusual immunophenotypes. Immunophenotypes were classified into four groups according to the degree of ectopic antigen expression. We classified as Group A (91.7%, 244 of 266 cases) those expressing conventional pattern without ectopic antigen. Group B (3.0%, 8 of 266 cases) was defined to have at least two lineage specific markers and single ectopic antigen. Such a "low grade deviation" did not prevent a definite immunodiagnosis. Group C (4.2%, 11 of 266 cases) revealed a promiscuous coexpression of markers related to different lineages, including two cases (0.8%, 2 cases) of biphenotypic leukemia. Group D (1.1%, 3 cases) included unclassifiable immunophenotypes with no antigen or HLA-DR only expression. Both patients with biphenotypic leukemia and one patient with unclassifiable immunophenotypes failed to respond to induction chemotherapy, suggesting a poor prognosis in these patients. The incidence of acute myelogenous leukemia (AML) cases with one or more ectopic surface antigens was 10 (8.1%) of the 124 AML cases. Ectopic antigen expression was seen in 5 (4%) of the 125 B-lineage acute lymphoblastic leukemia (ALL) cases and 3 (25%) of the 12 T-ALL cases. It is concluded that nearly 95% of cases of acute leukemia cases can be diagnosed accurately with immunophenotyping alone including patients with a mild degree of deviation from expected antigenic patterns.(ABSTRACT TRUNCATED AT 250 WORDS)
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spelling pubmed-30538392011-03-16 Acute leukemias with unusual immunophenotypes. Park, M. H. Yang, Y. S. Cho, H. I. Kim, B. K. Park, S. Ahn, H. S. Shin, H. Y. Kang, H. J. Oh, W. I. Kim, S. I. J Korean Med Sci Research Article Over a two-year period, immunophenotypic patterns of 266 acute leukemia cases were analyzed using a panel of tests including TdT, SmIg and 9 surface antigens by the immunofluorescence stains for the assessment of the incidence and grade of phenotypic ambiguity (lineage infidelity) and the possible clinical significance of unusual immunophenotypes. Immunophenotypes were classified into four groups according to the degree of ectopic antigen expression. We classified as Group A (91.7%, 244 of 266 cases) those expressing conventional pattern without ectopic antigen. Group B (3.0%, 8 of 266 cases) was defined to have at least two lineage specific markers and single ectopic antigen. Such a "low grade deviation" did not prevent a definite immunodiagnosis. Group C (4.2%, 11 of 266 cases) revealed a promiscuous coexpression of markers related to different lineages, including two cases (0.8%, 2 cases) of biphenotypic leukemia. Group D (1.1%, 3 cases) included unclassifiable immunophenotypes with no antigen or HLA-DR only expression. Both patients with biphenotypic leukemia and one patient with unclassifiable immunophenotypes failed to respond to induction chemotherapy, suggesting a poor prognosis in these patients. The incidence of acute myelogenous leukemia (AML) cases with one or more ectopic surface antigens was 10 (8.1%) of the 124 AML cases. Ectopic antigen expression was seen in 5 (4%) of the 125 B-lineage acute lymphoblastic leukemia (ALL) cases and 3 (25%) of the 12 T-ALL cases. It is concluded that nearly 95% of cases of acute leukemia cases can be diagnosed accurately with immunophenotyping alone including patients with a mild degree of deviation from expected antigenic patterns.(ABSTRACT TRUNCATED AT 250 WORDS) Korean Academy of Medical Sciences 1992-12 /pmc/articles/PMC3053839/ /pubmed/1299244 Text en
spellingShingle Research Article
Park, M. H.
Yang, Y. S.
Cho, H. I.
Kim, B. K.
Park, S.
Ahn, H. S.
Shin, H. Y.
Kang, H. J.
Oh, W. I.
Kim, S. I.
Acute leukemias with unusual immunophenotypes.
title Acute leukemias with unusual immunophenotypes.
title_full Acute leukemias with unusual immunophenotypes.
title_fullStr Acute leukemias with unusual immunophenotypes.
title_full_unstemmed Acute leukemias with unusual immunophenotypes.
title_short Acute leukemias with unusual immunophenotypes.
title_sort acute leukemias with unusual immunophenotypes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053839/
https://www.ncbi.nlm.nih.gov/pubmed/1299244
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