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Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.

The evaluation of prognostic factors in infants with critical stenosis of the aortic valve and intact ventricular septum is often misleading due to a complex interaction among lesions in the mitral and aortic valves, and the left ventricular myocardium. The clinical parameters on the left ventricula...

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Autores principales: Kim, S. H., Woo, H. O., Kim, Y. M., Han, J. J., Sohn, S. J., Bae, E. J., Lee, Y. T., Oh, M. H., Yoo, S. J., Seo, J. W.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054267/
https://www.ncbi.nlm.nih.gov/pubmed/9142660
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author Kim, S. H.
Woo, H. O.
Kim, Y. M.
Han, J. J.
Sohn, S. J.
Bae, E. J.
Lee, Y. T.
Oh, M. H.
Yoo, S. J.
Seo, J. W.
author_facet Kim, S. H.
Woo, H. O.
Kim, Y. M.
Han, J. J.
Sohn, S. J.
Bae, E. J.
Lee, Y. T.
Oh, M. H.
Yoo, S. J.
Seo, J. W.
author_sort Kim, S. H.
collection PubMed
description The evaluation of prognostic factors in infants with critical stenosis of the aortic valve and intact ventricular septum is often misleading due to a complex interaction among lesions in the mitral and aortic valves, and the left ventricular myocardium. The clinical parameters on the left ventricular function, such as ejection fraction and left ventricular end-diastolic volume, are of particular interest as their effects on survival are very controversial. We performed a clinicopathologic analysis of two autopsied cases of this disease. Besides the morphological hallmarks of the aortic and mitral valves, these two cases showed two extreme types of pathology in the left ventricular myocardium, which might have significant impacts on the clinical evaluation of the left ventricular function. Case 1 showed endocardial fibroelastosis associated with abnormal intertrabecular spaces (so-called spongy myocardium), obscuring accurate estimation of the left ventricular end-diastolic volume. Case 2 showed ischemic necrosis of the apical part of the left ventricular myocardium. This infarct was associated with acute and chronic subendocardial ischemia and mild endocardial fibroelastosis. Aggravation of the left ventricular failure could be caused by the recent ischemic insult. The evaluation of the left ventricular function, therefore, should include the evaluation of the morphologic status of the myocardium as regards to whether there is ischemia, endocardial fibroelastosis or hypertrophied trabeculae in addition to stenotic lesions in the aortic and mitral valves.
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spelling pubmed-30542672011-03-15 Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum. Kim, S. H. Woo, H. O. Kim, Y. M. Han, J. J. Sohn, S. J. Bae, E. J. Lee, Y. T. Oh, M. H. Yoo, S. J. Seo, J. W. J Korean Med Sci Research Article The evaluation of prognostic factors in infants with critical stenosis of the aortic valve and intact ventricular septum is often misleading due to a complex interaction among lesions in the mitral and aortic valves, and the left ventricular myocardium. The clinical parameters on the left ventricular function, such as ejection fraction and left ventricular end-diastolic volume, are of particular interest as their effects on survival are very controversial. We performed a clinicopathologic analysis of two autopsied cases of this disease. Besides the morphological hallmarks of the aortic and mitral valves, these two cases showed two extreme types of pathology in the left ventricular myocardium, which might have significant impacts on the clinical evaluation of the left ventricular function. Case 1 showed endocardial fibroelastosis associated with abnormal intertrabecular spaces (so-called spongy myocardium), obscuring accurate estimation of the left ventricular end-diastolic volume. Case 2 showed ischemic necrosis of the apical part of the left ventricular myocardium. This infarct was associated with acute and chronic subendocardial ischemia and mild endocardial fibroelastosis. Aggravation of the left ventricular failure could be caused by the recent ischemic insult. The evaluation of the left ventricular function, therefore, should include the evaluation of the morphologic status of the myocardium as regards to whether there is ischemia, endocardial fibroelastosis or hypertrophied trabeculae in addition to stenotic lesions in the aortic and mitral valves. Korean Academy of Medical Sciences 1997-02 /pmc/articles/PMC3054267/ /pubmed/9142660 Text en
spellingShingle Research Article
Kim, S. H.
Woo, H. O.
Kim, Y. M.
Han, J. J.
Sohn, S. J.
Bae, E. J.
Lee, Y. T.
Oh, M. H.
Yoo, S. J.
Seo, J. W.
Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title_full Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title_fullStr Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title_full_unstemmed Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title_short Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
title_sort abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054267/
https://www.ncbi.nlm.nih.gov/pubmed/9142660
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