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Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.

Cutaneous T-cell lymphomas (CTCL) represent a heterogeneous group of peripheral T-cell lymphomas arising in the skin and show considerable variations in clinicopathological features. This study was designed to examine viral genomes and cellular proliferation markers in CTCLs arising in Korea. On the...

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Detalles Bibliográficos
Autores principales: Kim, J. E., Huh, J., Cho, K., Kim, C. W.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054332/
https://www.ncbi.nlm.nih.gov/pubmed/9539316
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author Kim, J. E.
Huh, J.
Cho, K.
Kim, C. W.
author_facet Kim, J. E.
Huh, J.
Cho, K.
Kim, C. W.
author_sort Kim, J. E.
collection PubMed
description Cutaneous T-cell lymphomas (CTCL) represent a heterogeneous group of peripheral T-cell lymphomas arising in the skin and show considerable variations in clinicopathological features. This study was designed to examine viral genomes and cellular proliferation markers in CTCLs arising in Korea. On the basis of their morphologic characteristics and immunophenotypes, 43 cases of primary CTCL were classified, and evaluated for association with either HTLV-I or EBV, p53 protein immunoreactivity and Ki-67 labeling index (LI). EBV was demonstrated in 15 cases (35%) either by EBER in-situ hybridization or PCR; particularly high rates were exhibited by angiocentric T-cell lymphomas. PCR was used to detect HTLV-I proviral DNA, but none was found. The p53 expression rate was higher in large cell lesions, but the Ki-67 LI failed to show any significant differences among the different types. We therefore concluded that in Korea, HTLV-I is less frequently associated with CTCL than in other endemic countries. EBV was found particularly in angiocentric lesions, regardless of cell size or degree of pleomorphism. Because of its high positive rates in high grade lesions, the p53 expression showed positive correlation with histologic grade; however, the Ki-67 labeling index did not correlate with the histologic grade in CTCL.
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spelling pubmed-30543322011-03-15 Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea. Kim, J. E. Huh, J. Cho, K. Kim, C. W. J Korean Med Sci Research Article Cutaneous T-cell lymphomas (CTCL) represent a heterogeneous group of peripheral T-cell lymphomas arising in the skin and show considerable variations in clinicopathological features. This study was designed to examine viral genomes and cellular proliferation markers in CTCLs arising in Korea. On the basis of their morphologic characteristics and immunophenotypes, 43 cases of primary CTCL were classified, and evaluated for association with either HTLV-I or EBV, p53 protein immunoreactivity and Ki-67 labeling index (LI). EBV was demonstrated in 15 cases (35%) either by EBER in-situ hybridization or PCR; particularly high rates were exhibited by angiocentric T-cell lymphomas. PCR was used to detect HTLV-I proviral DNA, but none was found. The p53 expression rate was higher in large cell lesions, but the Ki-67 LI failed to show any significant differences among the different types. We therefore concluded that in Korea, HTLV-I is less frequently associated with CTCL than in other endemic countries. EBV was found particularly in angiocentric lesions, regardless of cell size or degree of pleomorphism. Because of its high positive rates in high grade lesions, the p53 expression showed positive correlation with histologic grade; however, the Ki-67 labeling index did not correlate with the histologic grade in CTCL. Korean Academy of Medical Sciences 1998-02 /pmc/articles/PMC3054332/ /pubmed/9539316 Text en
spellingShingle Research Article
Kim, J. E.
Huh, J.
Cho, K.
Kim, C. W.
Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title_full Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title_fullStr Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title_full_unstemmed Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title_short Pathologic characteristics of primary cutaneous T-cell lymphoma in Korea.
title_sort pathologic characteristics of primary cutaneous t-cell lymphoma in korea.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054332/
https://www.ncbi.nlm.nih.gov/pubmed/9539316
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