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Molecular bases of coronary heart disease in Koreans.

Coronary heart disease (CHD) has been considered as a multifactorial disorder with the involvement of both environmental and genetic factors. The advent of tools to investigate individual variability of DNA has allowed us to perform the association studies of candidate genes. However, an association...

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Detalles Bibliográficos
Autores principales: Kim, J. Q., Song, J., Park, Y. B., Hong, S. H.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054341/
https://www.ncbi.nlm.nih.gov/pubmed/9539312
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author Kim, J. Q.
Song, J.
Park, Y. B.
Hong, S. H.
author_facet Kim, J. Q.
Song, J.
Park, Y. B.
Hong, S. H.
author_sort Kim, J. Q.
collection PubMed
description Coronary heart disease (CHD) has been considered as a multifactorial disorder with the involvement of both environmental and genetic factors. The advent of tools to investigate individual variability of DNA has allowed us to perform the association studies of candidate genes. However, an association between genetic trait and phenotypic variations is not easy to demonstrate and several reported association between genetic markers and risk factors or overt CHD have gone unconfirmed. It should not be assumed that for a given genetic trait, the impact on risk will be similar in all populations. In particular, most studies of the molecular bases of CHD have involved Caucasian subjects, so much more work with the Korean population is needed before genetic testing for susceptibility to CHD can be offered to Koreans as a clinical service. In this review, we discuss two aspects of the molecular bases of CHD: i) Molecular bases of the candidate gene related to lipoprotein metabolism including apolipoprotein AI-CIII-AIV gene duster, apolipoprotein B, apolipoprotein E-CI-CII gene cluster, apolipoprotein(a), LDL receptors, lipoprotein lipase, cholesteryl ester transfer protein, and apo B editing protein; ii) Molecular bases of the candidate gene related to thrombotic and other factors including fibrinogen, factor VII, plasminogen activator inhibitor 1, homocysteine, stromelysin, paraoxonase, and angiotensin converting enzyme. Studies involving the Korean population, especially those performed by our teams, are also summarized.
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spelling pubmed-30543412011-03-15 Molecular bases of coronary heart disease in Koreans. Kim, J. Q. Song, J. Park, Y. B. Hong, S. H. J Korean Med Sci Research Article Coronary heart disease (CHD) has been considered as a multifactorial disorder with the involvement of both environmental and genetic factors. The advent of tools to investigate individual variability of DNA has allowed us to perform the association studies of candidate genes. However, an association between genetic trait and phenotypic variations is not easy to demonstrate and several reported association between genetic markers and risk factors or overt CHD have gone unconfirmed. It should not be assumed that for a given genetic trait, the impact on risk will be similar in all populations. In particular, most studies of the molecular bases of CHD have involved Caucasian subjects, so much more work with the Korean population is needed before genetic testing for susceptibility to CHD can be offered to Koreans as a clinical service. In this review, we discuss two aspects of the molecular bases of CHD: i) Molecular bases of the candidate gene related to lipoprotein metabolism including apolipoprotein AI-CIII-AIV gene duster, apolipoprotein B, apolipoprotein E-CI-CII gene cluster, apolipoprotein(a), LDL receptors, lipoprotein lipase, cholesteryl ester transfer protein, and apo B editing protein; ii) Molecular bases of the candidate gene related to thrombotic and other factors including fibrinogen, factor VII, plasminogen activator inhibitor 1, homocysteine, stromelysin, paraoxonase, and angiotensin converting enzyme. Studies involving the Korean population, especially those performed by our teams, are also summarized. Korean Academy of Medical Sciences 1998-02 /pmc/articles/PMC3054341/ /pubmed/9539312 Text en
spellingShingle Research Article
Kim, J. Q.
Song, J.
Park, Y. B.
Hong, S. H.
Molecular bases of coronary heart disease in Koreans.
title Molecular bases of coronary heart disease in Koreans.
title_full Molecular bases of coronary heart disease in Koreans.
title_fullStr Molecular bases of coronary heart disease in Koreans.
title_full_unstemmed Molecular bases of coronary heart disease in Koreans.
title_short Molecular bases of coronary heart disease in Koreans.
title_sort molecular bases of coronary heart disease in koreans.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054341/
https://www.ncbi.nlm.nih.gov/pubmed/9539312
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