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Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.

Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncoval...

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Detalles Bibliográficos
Autores principales: Joo, Y. E., Seo, K. S., Kim, J., Kim, H. S., Rew, J. S., Park, C. S., Kim, S. J.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054392/
https://www.ncbi.nlm.nih.gov/pubmed/10485622
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author Joo, Y. E.
Seo, K. S.
Kim, J.
Kim, H. S.
Rew, J. S.
Park, C. S.
Kim, S. J.
author_facet Joo, Y. E.
Seo, K. S.
Kim, J.
Kim, H. S.
Rew, J. S.
Park, C. S.
Kim, S. J.
author_sort Joo, Y. E.
collection PubMed
description Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-1 and TIMP-2 expressions in relation to clinicopathological variables in colorectal carcinoma with in situ hybridization and immunohistochemistry. TIMP-1 and TIMP-2 expressions were localized overwhelmingly to pericancer stromal cells, while malignant and normal mucosal cells were weak or negative. Strong stromal TIMP-1 immunoreactivity correlated with Dukes' stage (p=0.022), status of lymph node metastasis (p=0.044) and poor survival (p= 0.005). The degree of immunohistochemical staining of TIMP-2 did not correlate with all clinicopathological variables. The correlation between enhanced TIMP-1 expression and advanced stage and poor survival suggest a growth promoting activity of TIMP-1 in colorectal carcinoma.
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spelling pubmed-30543922011-03-15 Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma. Joo, Y. E. Seo, K. S. Kim, J. Kim, H. S. Rew, J. S. Park, C. S. Kim, S. J. J Korean Med Sci Research Article Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-1 and TIMP-2 expressions in relation to clinicopathological variables in colorectal carcinoma with in situ hybridization and immunohistochemistry. TIMP-1 and TIMP-2 expressions were localized overwhelmingly to pericancer stromal cells, while malignant and normal mucosal cells were weak or negative. Strong stromal TIMP-1 immunoreactivity correlated with Dukes' stage (p=0.022), status of lymph node metastasis (p=0.044) and poor survival (p= 0.005). The degree of immunohistochemical staining of TIMP-2 did not correlate with all clinicopathological variables. The correlation between enhanced TIMP-1 expression and advanced stage and poor survival suggest a growth promoting activity of TIMP-1 in colorectal carcinoma. Korean Academy of Medical Sciences 1999-08 /pmc/articles/PMC3054392/ /pubmed/10485622 Text en
spellingShingle Research Article
Joo, Y. E.
Seo, K. S.
Kim, J.
Kim, H. S.
Rew, J. S.
Park, C. S.
Kim, S. J.
Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title_full Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title_fullStr Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title_full_unstemmed Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title_short Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
title_sort role of tissue inhibitors of metalloproteinases (timps) in colorectal carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054392/
https://www.ncbi.nlm.nih.gov/pubmed/10485622
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