Cargando…

Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.

To evaluate whether the flow-mediated vasodilation and coronary flow reserve are impaired or not in patients with vasospastic angina (VA), we measured the changes of epicardial coronary artery diameter and flow reserve in spasm related-left anterior descending coronary artery (LAD). The flow mediate...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, S. H., Park, H. K., Lee, C. W., Kim, J. J., Hong, M. K., Park, S. W., Park, S. J.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054541/
https://www.ncbi.nlm.nih.gov/pubmed/9886166
_version_ 1782199970853552128
author Kang, S. H.
Park, H. K.
Lee, C. W.
Kim, J. J.
Hong, M. K.
Park, S. W.
Park, S. J.
author_facet Kang, S. H.
Park, H. K.
Lee, C. W.
Kim, J. J.
Hong, M. K.
Park, S. W.
Park, S. J.
author_sort Kang, S. H.
collection PubMed
description To evaluate whether the flow-mediated vasodilation and coronary flow reserve are impaired or not in patients with vasospastic angina (VA), we measured the changes of epicardial coronary artery diameter and flow reserve in spasm related-left anterior descending coronary artery (LAD). The flow mediated-response of epicardial coronary arteries in 15 VA were compared with 15 controls. Using quantitative coronary angiography, we measured the diameter of proximal (pLAD) and middle segment (mid-LAD) of LAD under baseline conditions, during increased blood flow after distal adenosine injection and after proximal administration of nitroglycerin. An increased fraction of average peak velocity after injection of adenosine was similar in both groups [control 340 (mean)+/-24 (SEM)%; VA 330+/-19%]. Flow-mediated vasodilation was preserved in all controls (pLAD 13.1+/-1.4%; mid-LAD 15.8+/-2.5%) but it was significantly impaired in patients with VA (pLAD -1.0+/-1.8%; mid-LAD 0.1+/-3.5%). The vasodilator response to nitroglycerin was comparable in controls (pLAD 25.8+/-2.8%; mid-LAD 27.2+/-2.8%) and VA (pLAD 26.2+/-5.2%; mid-LAD 26.7+/-3.5%). Coronary flow reserve is preserved in patients with VA. However, the flow-mediated response of spasm related-epicardial coronary artery is impaired. This may play an important role in the pathogenesis of coronary artery spasm.
format Text
id pubmed-3054541
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-30545412011-03-15 Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina. Kang, S. H. Park, H. K. Lee, C. W. Kim, J. J. Hong, M. K. Park, S. W. Park, S. J. J Korean Med Sci Research Article To evaluate whether the flow-mediated vasodilation and coronary flow reserve are impaired or not in patients with vasospastic angina (VA), we measured the changes of epicardial coronary artery diameter and flow reserve in spasm related-left anterior descending coronary artery (LAD). The flow mediated-response of epicardial coronary arteries in 15 VA were compared with 15 controls. Using quantitative coronary angiography, we measured the diameter of proximal (pLAD) and middle segment (mid-LAD) of LAD under baseline conditions, during increased blood flow after distal adenosine injection and after proximal administration of nitroglycerin. An increased fraction of average peak velocity after injection of adenosine was similar in both groups [control 340 (mean)+/-24 (SEM)%; VA 330+/-19%]. Flow-mediated vasodilation was preserved in all controls (pLAD 13.1+/-1.4%; mid-LAD 15.8+/-2.5%) but it was significantly impaired in patients with VA (pLAD -1.0+/-1.8%; mid-LAD 0.1+/-3.5%). The vasodilator response to nitroglycerin was comparable in controls (pLAD 25.8+/-2.8%; mid-LAD 27.2+/-2.8%) and VA (pLAD 26.2+/-5.2%; mid-LAD 26.7+/-3.5%). Coronary flow reserve is preserved in patients with VA. However, the flow-mediated response of spasm related-epicardial coronary artery is impaired. This may play an important role in the pathogenesis of coronary artery spasm. Korean Academy of Medical Sciences 1998-12 /pmc/articles/PMC3054541/ /pubmed/9886166 Text en
spellingShingle Research Article
Kang, S. H.
Park, H. K.
Lee, C. W.
Kim, J. J.
Hong, M. K.
Park, S. W.
Park, S. J.
Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title_full Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title_fullStr Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title_full_unstemmed Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title_short Impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
title_sort impaired flow-mediated vasodilation of epicardial coronary artery in vasospastic angina.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054541/
https://www.ncbi.nlm.nih.gov/pubmed/9886166
work_keys_str_mv AT kangsh impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT parkhk impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT leecw impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT kimjj impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT hongmk impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT parksw impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina
AT parksj impairedflowmediatedvasodilationofepicardialcoronaryarteryinvasospasticangina