Cargando…
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium.
The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 e...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Korean Academy of Medical Sciences
2000
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054585/ https://www.ncbi.nlm.nih.gov/pubmed/10719816 |
_version_ | 1782199981373915136 |
---|---|
author | Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. |
author_facet | Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. |
author_sort | Lee, Y. H. |
collection | PubMed |
description | The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal fibroblast-like cells and vascular endothelial cells. There was no significant difference in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly differed from that of COX-1 expression, being most intense in inflammatory cells. However, there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues. Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic RA synovium might be similar to those in chronic OA synovium. |
format | Text |
id | pubmed-3054585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-30545852011-03-15 Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. J Korean Med Sci Research Article The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal fibroblast-like cells and vascular endothelial cells. There was no significant difference in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly differed from that of COX-1 expression, being most intense in inflammatory cells. However, there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues. Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic RA synovium might be similar to those in chronic OA synovium. Korean Academy of Medical Sciences 2000-02 /pmc/articles/PMC3054585/ /pubmed/10719816 Text en |
spellingShingle | Research Article Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title | Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title_full | Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title_fullStr | Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title_full_unstemmed | Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title_short | Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
title_sort | expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054585/ https://www.ncbi.nlm.nih.gov/pubmed/10719816 |
work_keys_str_mv | AT leeyh expressionofcyclooxygenase1and2inrheumatoidarthritissynovium AT choisj expressionofcyclooxygenase1and2inrheumatoidarthritissynovium AT kima expressionofcyclooxygenase1and2inrheumatoidarthritissynovium AT kimch expressionofcyclooxygenase1and2inrheumatoidarthritissynovium AT jijd expressionofcyclooxygenase1and2inrheumatoidarthritissynovium AT songgg expressionofcyclooxygenase1and2inrheumatoidarthritissynovium |