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Adult T cell leukemia/lymphoma with lymphopenia in a Korean.
We experienced a case of adult T cell leukemia/lymphoma (ATLL) in a 48-year-old Korean female, who has never been abroad since birth and no history of blood transfusion. The patient had hypercalcemia and multiple lymphadenopathy. Histopathologic study of left cervical lymph node (LN) and bone marrow...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Korean Academy of Medical Sciences
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054617/ https://www.ncbi.nlm.nih.gov/pubmed/10803704 |
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author | Jeon, H. J. Lee, M. J. Jeong, Y. K. Lee, D. M. Oh, Y. K. Kim, C. W. |
author_facet | Jeon, H. J. Lee, M. J. Jeong, Y. K. Lee, D. M. Oh, Y. K. Kim, C. W. |
author_sort | Jeon, H. J. |
collection | PubMed |
description | We experienced a case of adult T cell leukemia/lymphoma (ATLL) in a 48-year-old Korean female, who has never been abroad since birth and no history of blood transfusion. The patient had hypercalcemia and multiple lymphadenopathy. Histopathologic study of left cervical lymph node (LN) and bone marrow (BM) revealed that infiltrates of malignant lymphoid cells were composed of small, medium and large cells with pleomorphic nuclei. Smears of peripheral blood (PB) showed lymphopenia (16%) with the appearance of a few atypical lymphoid cells (less than 2%), but not the typical clover leaf cells seen in ATLL. Immunophenotypic study of LN and BM revealed T cell phenotype. PB showed increased CD4+ T cell (T(H), CD3/CD4+, 57%) and decreased CD8+ T cell counts (T(S), CD3/CD8+, 6.7%). The sera of the patient and her family were reactive for HTLV-I antibody. The specific sequences of pol, env, and tax of HTLV-I DNA were detected in the lymphoma cells and peripheral blood mononuclear cells (PBMC) using polymerase chain reaction. Ultrastructural examination of PBMC confirmed numerous type c virus particles in extracellular space. This case was an acute type of ATLL without overt leukemic features in PB. Despite chemotherapy and intensive conservative treatment, she died 3 months after admission. |
format | Text |
id | pubmed-3054617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-30546172011-03-15 Adult T cell leukemia/lymphoma with lymphopenia in a Korean. Jeon, H. J. Lee, M. J. Jeong, Y. K. Lee, D. M. Oh, Y. K. Kim, C. W. J Korean Med Sci Research Article We experienced a case of adult T cell leukemia/lymphoma (ATLL) in a 48-year-old Korean female, who has never been abroad since birth and no history of blood transfusion. The patient had hypercalcemia and multiple lymphadenopathy. Histopathologic study of left cervical lymph node (LN) and bone marrow (BM) revealed that infiltrates of malignant lymphoid cells were composed of small, medium and large cells with pleomorphic nuclei. Smears of peripheral blood (PB) showed lymphopenia (16%) with the appearance of a few atypical lymphoid cells (less than 2%), but not the typical clover leaf cells seen in ATLL. Immunophenotypic study of LN and BM revealed T cell phenotype. PB showed increased CD4+ T cell (T(H), CD3/CD4+, 57%) and decreased CD8+ T cell counts (T(S), CD3/CD8+, 6.7%). The sera of the patient and her family were reactive for HTLV-I antibody. The specific sequences of pol, env, and tax of HTLV-I DNA were detected in the lymphoma cells and peripheral blood mononuclear cells (PBMC) using polymerase chain reaction. Ultrastructural examination of PBMC confirmed numerous type c virus particles in extracellular space. This case was an acute type of ATLL without overt leukemic features in PB. Despite chemotherapy and intensive conservative treatment, she died 3 months after admission. Korean Academy of Medical Sciences 2000-04 /pmc/articles/PMC3054617/ /pubmed/10803704 Text en |
spellingShingle | Research Article Jeon, H. J. Lee, M. J. Jeong, Y. K. Lee, D. M. Oh, Y. K. Kim, C. W. Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title | Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title_full | Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title_fullStr | Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title_full_unstemmed | Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title_short | Adult T cell leukemia/lymphoma with lymphopenia in a Korean. |
title_sort | adult t cell leukemia/lymphoma with lymphopenia in a korean. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054617/ https://www.ncbi.nlm.nih.gov/pubmed/10803704 |
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