The levels of MDM2 protein are decreased by a proteasome-mediated proteolysis prior to caspase-3-dependent pRb and PARP cleavages.

MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a ubiquitin-dependent proteasome pathway in the absence of p53. When HL-60 cells, p53 null, were tre...

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Detalles Bibliográficos
Autores principales: Cho, J. W., Park, J. C., Lee, J. C., Kwon, T. K., Park, J. W., Baek, W. K., Suh, S. I., Suh, M. H.
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054727/
https://www.ncbi.nlm.nih.gov/pubmed/11306736

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