Differential expressions of Fas and Fas ligand in human placenta.

To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52...

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Detalles Bibliográficos
Autores principales: Roh, Cheong-Rae, Lee, Jeong-Won, Kang, Byung-Hee, Yang, Soon-Ha, Kim, Byoung-Gie, Bae, Duk-Soo, Kim, Jong-Hwa, Lee, Je-Ho
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054862/
https://www.ncbi.nlm.nih.gov/pubmed/11961305
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author Roh, Cheong-Rae
Lee, Jeong-Won
Kang, Byung-Hee
Yang, Soon-Ha
Kim, Byoung-Gie
Bae, Duk-Soo
Kim, Jong-Hwa
Lee, Je-Ho
author_facet Roh, Cheong-Rae
Lee, Jeong-Won
Kang, Byung-Hee
Yang, Soon-Ha
Kim, Byoung-Gie
Bae, Duk-Soo
Kim, Jong-Hwa
Lee, Je-Ho
author_sort Roh, Cheong-Rae
collection PubMed
description To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.
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spelling pubmed-30548622011-03-15 Differential expressions of Fas and Fas ligand in human placenta. Roh, Cheong-Rae Lee, Jeong-Won Kang, Byung-Hee Yang, Soon-Ha Kim, Byoung-Gie Bae, Duk-Soo Kim, Jong-Hwa Lee, Je-Ho J Korean Med Sci Research Article To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia. Korean Academy of Medical Sciences 2002-04 /pmc/articles/PMC3054862/ /pubmed/11961305 Text en
spellingShingle Research Article
Roh, Cheong-Rae
Lee, Jeong-Won
Kang, Byung-Hee
Yang, Soon-Ha
Kim, Byoung-Gie
Bae, Duk-Soo
Kim, Jong-Hwa
Lee, Je-Ho
Differential expressions of Fas and Fas ligand in human placenta.
title Differential expressions of Fas and Fas ligand in human placenta.
title_full Differential expressions of Fas and Fas ligand in human placenta.
title_fullStr Differential expressions of Fas and Fas ligand in human placenta.
title_full_unstemmed Differential expressions of Fas and Fas ligand in human placenta.
title_short Differential expressions of Fas and Fas ligand in human placenta.
title_sort differential expressions of fas and fas ligand in human placenta.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054862/
https://www.ncbi.nlm.nih.gov/pubmed/11961305
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