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The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.

Neuropathological deficits are an etiological factor in Tourette syndrome (TS), and implicate a network linking the basal ganglia and the cerebrum, not a particular single brain region. In this study, the volumes of 20 cerebral and cerebellar regions and their symmetries were measured in normal boys...

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Autores principales: Hong, Kang-E, Ock, Sun-Myeong, Kang, Min-Hee, Kim, Chul-Eung, Bae, Jae-Nam, Lim, Myung-Kwan, Suh, Chang-Hae, Chung, Sun-Ju, Cho, Soo-Churl, Lee, Jeong-Seop
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054894/
https://www.ncbi.nlm.nih.gov/pubmed/12172051
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author Hong, Kang-E
Ock, Sun-Myeong
Kang, Min-Hee
Kim, Chul-Eung
Bae, Jae-Nam
Lim, Myung-Kwan
Suh, Chang-Hae
Chung, Sun-Ju
Cho, Soo-Churl
Lee, Jeong-Seop
author_facet Hong, Kang-E
Ock, Sun-Myeong
Kang, Min-Hee
Kim, Chul-Eung
Bae, Jae-Nam
Lim, Myung-Kwan
Suh, Chang-Hae
Chung, Sun-Ju
Cho, Soo-Churl
Lee, Jeong-Seop
author_sort Hong, Kang-E
collection PubMed
description Neuropathological deficits are an etiological factor in Tourette syndrome (TS), and implicate a network linking the basal ganglia and the cerebrum, not a particular single brain region. In this study, the volumes of 20 cerebral and cerebellar regions and their symmetries were measured in normal boys and TS boys by brain magnetic resonance imaging. Brain magnetic resonance images were obtained prospectively in 19 boys with TS and 17 age-matched normal control boys. Cerebral and cerebellar regions were segmented to gray and white fractions using algorithm for semi-automated fuzzy tissue segmentation. The frontal, parietal, temporal, and the occipital lobes and the cerebellum were defined using the semiautomated Talairach atlas-based parcellation method. Boys with TS had smaller total brain volumes than control subjects. In the gray matter, although the smaller brain volume was taken into account, TS boys had a smaller right frontal lobe and a larger left frontal lobe and increased normal asymmetry (left>right). In addition, TS boys had more frontal lobe white matter. There were no significant differences in regions of interest of the parietal, temporal, or the occipital lobes or the cerebellum. These findings suggest that boys with TS may have neuropathological abnormalities in the gray and the white matter of the frontal lobe.
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spelling pubmed-30548942011-03-15 The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome. Hong, Kang-E Ock, Sun-Myeong Kang, Min-Hee Kim, Chul-Eung Bae, Jae-Nam Lim, Myung-Kwan Suh, Chang-Hae Chung, Sun-Ju Cho, Soo-Churl Lee, Jeong-Seop J Korean Med Sci Research Article Neuropathological deficits are an etiological factor in Tourette syndrome (TS), and implicate a network linking the basal ganglia and the cerebrum, not a particular single brain region. In this study, the volumes of 20 cerebral and cerebellar regions and their symmetries were measured in normal boys and TS boys by brain magnetic resonance imaging. Brain magnetic resonance images were obtained prospectively in 19 boys with TS and 17 age-matched normal control boys. Cerebral and cerebellar regions were segmented to gray and white fractions using algorithm for semi-automated fuzzy tissue segmentation. The frontal, parietal, temporal, and the occipital lobes and the cerebellum were defined using the semiautomated Talairach atlas-based parcellation method. Boys with TS had smaller total brain volumes than control subjects. In the gray matter, although the smaller brain volume was taken into account, TS boys had a smaller right frontal lobe and a larger left frontal lobe and increased normal asymmetry (left>right). In addition, TS boys had more frontal lobe white matter. There were no significant differences in regions of interest of the parietal, temporal, or the occipital lobes or the cerebellum. These findings suggest that boys with TS may have neuropathological abnormalities in the gray and the white matter of the frontal lobe. Korean Academy of Medical Sciences 2002-08 /pmc/articles/PMC3054894/ /pubmed/12172051 Text en
spellingShingle Research Article
Hong, Kang-E
Ock, Sun-Myeong
Kang, Min-Hee
Kim, Chul-Eung
Bae, Jae-Nam
Lim, Myung-Kwan
Suh, Chang-Hae
Chung, Sun-Ju
Cho, Soo-Churl
Lee, Jeong-Seop
The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title_full The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title_fullStr The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title_full_unstemmed The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title_short The segmented regional volumes of the cerebrum and cerebellum in boys with Tourette syndrome.
title_sort segmented regional volumes of the cerebrum and cerebellum in boys with tourette syndrome.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054894/
https://www.ncbi.nlm.nih.gov/pubmed/12172051
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