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Angiogenesis and mineralization during distraction osteogenesis.

Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts of bone can be regenerated in the distraction gap. Mechanical stimulation by distraction induces biologic...

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Detalles Bibliográficos
Autores principales: Choi, In Ho, Chung, Chin Youb, Cho, Tae-Joon, Yoo, Won Joon
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054899/
https://www.ncbi.nlm.nih.gov/pubmed/12172035
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author Choi, In Ho
Chung, Chin Youb
Cho, Tae-Joon
Yoo, Won Joon
author_facet Choi, In Ho
Chung, Chin Youb
Cho, Tae-Joon
Yoo, Won Joon
author_sort Choi, In Ho
collection PubMed
description Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts of bone can be regenerated in the distraction gap. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes that may include differentiation of pluripotential tissue, angiogenesis, mineralization, and remodeling. There are complex interactions between bone-forming osteoblasts and other cells present within the bone microenvironment, particularly vascular endothelial cells that may be pivotal members of a complex interactive communication network in bone. Regenerate bone forms by three modes of ossification, which include intramembranous, enchondral, and transchondroid ossifications, although intramembraneous bone formation is the predominant mechanism of ossification. In this review we discussed the coupling between angiogenesis and mineralization, the biological and mechanical factors affecting them, the cellular and molecular events occurring during distraction osteogenesis, and the emerging modalities to accelerate regenerate bone healing and remodeling.
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spelling pubmed-30548992011-03-15 Angiogenesis and mineralization during distraction osteogenesis. Choi, In Ho Chung, Chin Youb Cho, Tae-Joon Yoo, Won Joon J Korean Med Sci Research Article Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts of bone can be regenerated in the distraction gap. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes that may include differentiation of pluripotential tissue, angiogenesis, mineralization, and remodeling. There are complex interactions between bone-forming osteoblasts and other cells present within the bone microenvironment, particularly vascular endothelial cells that may be pivotal members of a complex interactive communication network in bone. Regenerate bone forms by three modes of ossification, which include intramembranous, enchondral, and transchondroid ossifications, although intramembraneous bone formation is the predominant mechanism of ossification. In this review we discussed the coupling between angiogenesis and mineralization, the biological and mechanical factors affecting them, the cellular and molecular events occurring during distraction osteogenesis, and the emerging modalities to accelerate regenerate bone healing and remodeling. Korean Academy of Medical Sciences 2002-08 /pmc/articles/PMC3054899/ /pubmed/12172035 Text en
spellingShingle Research Article
Choi, In Ho
Chung, Chin Youb
Cho, Tae-Joon
Yoo, Won Joon
Angiogenesis and mineralization during distraction osteogenesis.
title Angiogenesis and mineralization during distraction osteogenesis.
title_full Angiogenesis and mineralization during distraction osteogenesis.
title_fullStr Angiogenesis and mineralization during distraction osteogenesis.
title_full_unstemmed Angiogenesis and mineralization during distraction osteogenesis.
title_short Angiogenesis and mineralization during distraction osteogenesis.
title_sort angiogenesis and mineralization during distraction osteogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054899/
https://www.ncbi.nlm.nih.gov/pubmed/12172035
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