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A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.
Treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (t-AML) are now well established as complications of cytotoxic chemotherapy. We experienced a 28-yr-old female patient who developed t-MDS/t-AML with characteristic chromosomal abnormalities including 11q23 chromosomal...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Academy of Medical Sciences
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054920/ https://www.ncbi.nlm.nih.gov/pubmed/12172056 |
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author | Jang, Geun Doo Kim, Sang-We Suh, Cheol Won Kim, Eun-Kyoung Bahng, Hye Seung Jeong, Young Hoon Park, Il Gwon Kim, Woo-Kun Kim, Sang-Hee Suh, Eul-Ju Park, Chan-Jeoung Ji, Hyun-Sook Lee, Jung-Shin |
author_facet | Jang, Geun Doo Kim, Sang-We Suh, Cheol Won Kim, Eun-Kyoung Bahng, Hye Seung Jeong, Young Hoon Park, Il Gwon Kim, Woo-Kun Kim, Sang-Hee Suh, Eul-Ju Park, Chan-Jeoung Ji, Hyun-Sook Lee, Jung-Shin |
author_sort | Jang, Geun Doo |
collection | PubMed |
description | Treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (t-AML) are now well established as complications of cytotoxic chemotherapy. We experienced a 28-yr-old female patient who developed t-MDS/t-AML with characteristic chromosomal abnormalities including 11q23 chromosomal rearrangement following high-dose chemotherapy with autologous stem cell transplantation (ASCT) for non-Hodgkin's lymphoma. The patient was admitted with bulky abdominal masses of B cell lineage non-Hodgkin's lymphoma. After 2 cycles of systemic chemotherapy of the Vanderbilt regimen, the patient underwent ASCT with high dose chemotherapy of the BEAC regimen. She also received radiation of 48 Gy for the residual periportal lymphadenopathy. The initial cytogenetic analysis of the infused mononuclear cells revealed a normal karyotype. Twenty two months after the ASCT, pancytopenia was noted and her bone marrow aspirate showed dysplastic hemopoiesis with myeloblasts up to 12% of nonerythroid nucleated cells. The patient was diagnosed as t-MDS (refractory anemia with an excess of blasts). Cytogenetic analysis showed complex chromosomal abnormalities including 11q23 rearrangement, which is frequently found in topoisomerase II inhibitor-related hematologic malignancies. Four months later, it was noted that the t-MDS had evolved into an overt t-AML. Cytogenetic analysis showed an evolving pattern with more complex abnormalities. The patient was treated with combination chemotherapy, but her leukemic cells were resistant to the therapy. |
format | Text |
id | pubmed-3054920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-30549202011-03-15 A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. Jang, Geun Doo Kim, Sang-We Suh, Cheol Won Kim, Eun-Kyoung Bahng, Hye Seung Jeong, Young Hoon Park, Il Gwon Kim, Woo-Kun Kim, Sang-Hee Suh, Eul-Ju Park, Chan-Jeoung Ji, Hyun-Sook Lee, Jung-Shin J Korean Med Sci Research Article Treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (t-AML) are now well established as complications of cytotoxic chemotherapy. We experienced a 28-yr-old female patient who developed t-MDS/t-AML with characteristic chromosomal abnormalities including 11q23 chromosomal rearrangement following high-dose chemotherapy with autologous stem cell transplantation (ASCT) for non-Hodgkin's lymphoma. The patient was admitted with bulky abdominal masses of B cell lineage non-Hodgkin's lymphoma. After 2 cycles of systemic chemotherapy of the Vanderbilt regimen, the patient underwent ASCT with high dose chemotherapy of the BEAC regimen. She also received radiation of 48 Gy for the residual periportal lymphadenopathy. The initial cytogenetic analysis of the infused mononuclear cells revealed a normal karyotype. Twenty two months after the ASCT, pancytopenia was noted and her bone marrow aspirate showed dysplastic hemopoiesis with myeloblasts up to 12% of nonerythroid nucleated cells. The patient was diagnosed as t-MDS (refractory anemia with an excess of blasts). Cytogenetic analysis showed complex chromosomal abnormalities including 11q23 rearrangement, which is frequently found in topoisomerase II inhibitor-related hematologic malignancies. Four months later, it was noted that the t-MDS had evolved into an overt t-AML. Cytogenetic analysis showed an evolving pattern with more complex abnormalities. The patient was treated with combination chemotherapy, but her leukemic cells were resistant to the therapy. Korean Academy of Medical Sciences 2002-08 /pmc/articles/PMC3054920/ /pubmed/12172056 Text en |
spellingShingle | Research Article Jang, Geun Doo Kim, Sang-We Suh, Cheol Won Kim, Eun-Kyoung Bahng, Hye Seung Jeong, Young Hoon Park, Il Gwon Kim, Woo-Kun Kim, Sang-Hee Suh, Eul-Ju Park, Chan-Jeoung Ji, Hyun-Sook Lee, Jung-Shin A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title_full | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title_fullStr | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title_full_unstemmed | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title_short | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. |
title_sort | case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-hodgkin's lymphoma. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054920/ https://www.ncbi.nlm.nih.gov/pubmed/12172056 |
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