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Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.

We investigated the combined effect of glutamine (GLN) and growth hormone (GH) on bacterial translocation (BT) in sepsis. After single intraperitoneal injection of lipopolysaccharide (10 mg/kg), 48 rats were divided randomly into four groups of 12 animals each: the control group received chow orally...

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Autores principales: Jung, Sung-Eun, Youn, Yeo-Kyu, Lim, Yong-Su, Song, Hyoung-Gon, Rhee, Joong-Eui, Suh, Gil-Joon
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055004/
https://www.ncbi.nlm.nih.gov/pubmed/12589081
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author Jung, Sung-Eun
Youn, Yeo-Kyu
Lim, Yong-Su
Song, Hyoung-Gon
Rhee, Joong-Eui
Suh, Gil-Joon
author_facet Jung, Sung-Eun
Youn, Yeo-Kyu
Lim, Yong-Su
Song, Hyoung-Gon
Rhee, Joong-Eui
Suh, Gil-Joon
author_sort Jung, Sung-Eun
collection PubMed
description We investigated the combined effect of glutamine (GLN) and growth hormone (GH) on bacterial translocation (BT) in sepsis. After single intraperitoneal injection of lipopolysaccharide (10 mg/kg), 48 rats were divided randomly into four groups of 12 animals each: the control group received chow orally; the GLN group received chow plus 10% GLN; GH group received chow plus GH; and the GLN/GH group received chow, 10% GLN, and GH. Twenty-four and 96 hr later, rats were sacrificed. Portal blood culture, bacterial colony counts of cultured mesenteric lymph nodes, mucosal thickness, malondialdehyde (MDA), and glutathione (GSH) levels in the gut mucosa were measured. There was no significant change of the rate of portal blood culture between all treatment groups at 24 and 96 hr. At 24 hr, the rats receiving combined treatment of GLN and GH showed lower bacterial colony counts and mucosal MDA levels than the control rats, and higher mucosal GSH levels than the control and GLN-treated rats. At 96 hr, rats treated with both GLN and GH exhibited lower bacterial colony counts and mucosal MDA levels, and higher mucosal thickness and GSH levels than control, GLN, or GH-treated rats. This study suggests that the combination of GLN and GH may synergistically reduce BT over time in sepsis.
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spelling pubmed-30550042011-03-15 Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis. Jung, Sung-Eun Youn, Yeo-Kyu Lim, Yong-Su Song, Hyoung-Gon Rhee, Joong-Eui Suh, Gil-Joon J Korean Med Sci Research Article We investigated the combined effect of glutamine (GLN) and growth hormone (GH) on bacterial translocation (BT) in sepsis. After single intraperitoneal injection of lipopolysaccharide (10 mg/kg), 48 rats were divided randomly into four groups of 12 animals each: the control group received chow orally; the GLN group received chow plus 10% GLN; GH group received chow plus GH; and the GLN/GH group received chow, 10% GLN, and GH. Twenty-four and 96 hr later, rats were sacrificed. Portal blood culture, bacterial colony counts of cultured mesenteric lymph nodes, mucosal thickness, malondialdehyde (MDA), and glutathione (GSH) levels in the gut mucosa were measured. There was no significant change of the rate of portal blood culture between all treatment groups at 24 and 96 hr. At 24 hr, the rats receiving combined treatment of GLN and GH showed lower bacterial colony counts and mucosal MDA levels than the control rats, and higher mucosal GSH levels than the control and GLN-treated rats. At 96 hr, rats treated with both GLN and GH exhibited lower bacterial colony counts and mucosal MDA levels, and higher mucosal thickness and GSH levels than control, GLN, or GH-treated rats. This study suggests that the combination of GLN and GH may synergistically reduce BT over time in sepsis. Korean Academy of Medical Sciences 2003-02 /pmc/articles/PMC3055004/ /pubmed/12589081 Text en
spellingShingle Research Article
Jung, Sung-Eun
Youn, Yeo-Kyu
Lim, Yong-Su
Song, Hyoung-Gon
Rhee, Joong-Eui
Suh, Gil-Joon
Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title_full Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title_fullStr Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title_full_unstemmed Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title_short Combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
title_sort combined administration of glutamine and growth hormone synergistically reduces bacterial translocation in sepsis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055004/
https://www.ncbi.nlm.nih.gov/pubmed/12589081
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