Cargando…

Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.

The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Ho-Sung, Hong, Sung-Hee, Kang, Hee-Jun, Ko, Byung Kyun, Ahn, Sei-Hyun, Huh, Joo-Ryung
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055024/
https://www.ncbi.nlm.nih.gov/pubmed/12692420
_version_ 1782200087037870080
author Yoon, Ho-Sung
Hong, Sung-Hee
Kang, Hee-Jun
Ko, Byung Kyun
Ahn, Sei-Hyun
Huh, Joo-Ryung
author_facet Yoon, Ho-Sung
Hong, Sung-Hee
Kang, Hee-Jun
Ko, Byung Kyun
Ahn, Sei-Hyun
Huh, Joo-Ryung
author_sort Yoon, Ho-Sung
collection PubMed
description The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic factors. The median relative ratio was 3.0 (range, 0.12-26.83) and the Bfl-1 gene expression rate was 36.7% (11/30). There was no statistically significant relationship between the clinicopathologic parameters of patients and the expression value of Bfl-1 gene. The level of Bfl-1 gene expression was higher in more advanced breast cancers than in early cancers. There was no significant relationship between the expression values and currently acknowledged prognostic factors, but a higher expression pattern was noticed in the groups of positive hormone receptors and negative p53 and negative c-erbB2, albeit statistically not significant. It seems that the increased expression of the Bfl-1 gene serves as a contributory factor in breast cancer, in the same way that another group of genes, the Bcl-2 family, contributes to apoptosis.
format Text
id pubmed-3055024
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-30550242011-03-15 Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors. Yoon, Ho-Sung Hong, Sung-Hee Kang, Hee-Jun Ko, Byung Kyun Ahn, Sei-Hyun Huh, Joo-Ryung J Korean Med Sci Research Article The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic factors. The median relative ratio was 3.0 (range, 0.12-26.83) and the Bfl-1 gene expression rate was 36.7% (11/30). There was no statistically significant relationship between the clinicopathologic parameters of patients and the expression value of Bfl-1 gene. The level of Bfl-1 gene expression was higher in more advanced breast cancers than in early cancers. There was no significant relationship between the expression values and currently acknowledged prognostic factors, but a higher expression pattern was noticed in the groups of positive hormone receptors and negative p53 and negative c-erbB2, albeit statistically not significant. It seems that the increased expression of the Bfl-1 gene serves as a contributory factor in breast cancer, in the same way that another group of genes, the Bcl-2 family, contributes to apoptosis. Korean Academy of Medical Sciences 2003-04 /pmc/articles/PMC3055024/ /pubmed/12692420 Text en
spellingShingle Research Article
Yoon, Ho-Sung
Hong, Sung-Hee
Kang, Hee-Jun
Ko, Byung Kyun
Ahn, Sei-Hyun
Huh, Joo-Ryung
Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title_full Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title_fullStr Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title_full_unstemmed Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title_short Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
title_sort bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055024/
https://www.ncbi.nlm.nih.gov/pubmed/12692420
work_keys_str_mv AT yoonhosung bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors
AT hongsunghee bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors
AT kangheejun bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors
AT kobyungkyun bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors
AT ahnseihyun bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors
AT huhjooryung bfl1geneexpressioninbreastcanceritsrelationshipwithotherprognosticfactors