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The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.

Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential fa...

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Autores principales: Chang, Hyuk-Jae, Chung, Jaehoon, Choi, Byoung-Joo, Choi, Tae-Young, Choi, So-Yeon, Yoon, Myeong-Ho, Hwang, Gyo-Seung, Shin, Joon-Han, Tahk, Seung-Jea, Choi, Byung-Il William
Formato: Texto
Lenguaje:English
Publicado: Korean Academy of Medical Sciences 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055142/
https://www.ncbi.nlm.nih.gov/pubmed/14676433
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author Chang, Hyuk-Jae
Chung, Jaehoon
Choi, Byoung-Joo
Choi, Tae-Young
Choi, So-Yeon
Yoon, Myeong-Ho
Hwang, Gyo-Seung
Shin, Joon-Han
Tahk, Seung-Jea
Choi, Byung-Il William
author_facet Chang, Hyuk-Jae
Chung, Jaehoon
Choi, Byoung-Joo
Choi, Tae-Young
Choi, So-Yeon
Yoon, Myeong-Ho
Hwang, Gyo-Seung
Shin, Joon-Han
Tahk, Seung-Jea
Choi, Byung-Il William
author_sort Chang, Hyuk-Jae
collection PubMed
description Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and soluble tumor necrosis factor-alpha receptor (sTNFR) I, II. TNF-alpha at CS (3.25 +/- 0.34 pg/mL) was higher than those of SA (1.81 +/- 0.39 pg/mL) and IVC (1.88 +/- 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 +/- 3.8 pg/mL) was higher than that of SA (5.8 +/- 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-alpha and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-alpha from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.
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spelling pubmed-30551422011-03-15 The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy. Chang, Hyuk-Jae Chung, Jaehoon Choi, Byoung-Joo Choi, Tae-Young Choi, So-Yeon Yoon, Myeong-Ho Hwang, Gyo-Seung Shin, Joon-Han Tahk, Seung-Jea Choi, Byung-Il William J Korean Med Sci Research Article Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and soluble tumor necrosis factor-alpha receptor (sTNFR) I, II. TNF-alpha at CS (3.25 +/- 0.34 pg/mL) was higher than those of SA (1.81 +/- 0.39 pg/mL) and IVC (1.88 +/- 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 +/- 3.8 pg/mL) was higher than that of SA (5.8 +/- 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-alpha and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-alpha from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy. Korean Academy of Medical Sciences 2003-12 /pmc/articles/PMC3055142/ /pubmed/14676433 Text en
spellingShingle Research Article
Chang, Hyuk-Jae
Chung, Jaehoon
Choi, Byoung-Joo
Choi, Tae-Young
Choi, So-Yeon
Yoon, Myeong-Ho
Hwang, Gyo-Seung
Shin, Joon-Han
Tahk, Seung-Jea
Choi, Byung-Il William
The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title_full The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title_fullStr The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title_full_unstemmed The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title_short The origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
title_sort origin of proinflammatory cytokines in patients with idiopathic dilated cardiomyopathy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055142/
https://www.ncbi.nlm.nih.gov/pubmed/14676433
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