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The prognosis of liver cirrhosis in recent years in Korea.
The survival of a recent series of 823 cirrhosis patients who were followed up for a mean of 48 months was analyzed. Cirrhosis was ascribed to alcohol (26%), hepatitis virus B (58%), hepatitis virus C (11%) or both (2%), or was cryptogenic (3%). Features of decompensation were observed in 51% of the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Academy of Medical Sciences
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055146/ https://www.ncbi.nlm.nih.gov/pubmed/14676440 |
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author | Kim, Young Sun Um, Soon Ho Ryu, Ho Sang Lee, Jung Bok Lee, Jae Won Park, Dong Kyu Kim, Yong Sik Jin, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Lee, Sang Woo Choi, Jai Hyun Kim, Chang Duck Hyun, Jin Hai |
author_facet | Kim, Young Sun Um, Soon Ho Ryu, Ho Sang Lee, Jung Bok Lee, Jae Won Park, Dong Kyu Kim, Yong Sik Jin, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Lee, Sang Woo Choi, Jai Hyun Kim, Chang Duck Hyun, Jin Hai |
author_sort | Kim, Young Sun |
collection | PubMed |
description | The survival of a recent series of 823 cirrhosis patients who were followed up for a mean of 48 months was analyzed. Cirrhosis was ascribed to alcohol (26%), hepatitis virus B (58%), hepatitis virus C (11%) or both (2%), or was cryptogenic (3%). Features of decompensation were observed in 51% of the patients at entry, and newly developed in 44% of compensated patients within 5 yr. The 5-yr survival after decompensation was 25%. The leading causes of death were liver failure (53%), hepatocellular carcinoma (HCC, 23%), and variceal bleeding (10%). Early detection of HCC significantly improved the survival of cirrhosis patients. Biannual ultrasonography increased the detection rate of small HCC. Mortality of variceal hemorrhage was much lower in patients with Child-Pugh scores from 5 to 8 than in those with scores above 8 (5% vs. 52%). Endoscopic prophylaxis significantly decreased the incidence of first variceal hemorrhage, but the effect was insufficient to improve the rate of survival. Mortality of first spontaneous bacterial peritonitis was 18%. These data suggest that the mortality of major complications of liver cirrhosis has considerably decreased during the last two decades, while there was no remarkable improvement in long-term survival. More efficient management of etiologic factors would be required. |
format | Text |
id | pubmed-3055146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-30551462011-03-15 The prognosis of liver cirrhosis in recent years in Korea. Kim, Young Sun Um, Soon Ho Ryu, Ho Sang Lee, Jung Bok Lee, Jae Won Park, Dong Kyu Kim, Yong Sik Jin, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Lee, Sang Woo Choi, Jai Hyun Kim, Chang Duck Hyun, Jin Hai J Korean Med Sci Research Article The survival of a recent series of 823 cirrhosis patients who were followed up for a mean of 48 months was analyzed. Cirrhosis was ascribed to alcohol (26%), hepatitis virus B (58%), hepatitis virus C (11%) or both (2%), or was cryptogenic (3%). Features of decompensation were observed in 51% of the patients at entry, and newly developed in 44% of compensated patients within 5 yr. The 5-yr survival after decompensation was 25%. The leading causes of death were liver failure (53%), hepatocellular carcinoma (HCC, 23%), and variceal bleeding (10%). Early detection of HCC significantly improved the survival of cirrhosis patients. Biannual ultrasonography increased the detection rate of small HCC. Mortality of variceal hemorrhage was much lower in patients with Child-Pugh scores from 5 to 8 than in those with scores above 8 (5% vs. 52%). Endoscopic prophylaxis significantly decreased the incidence of first variceal hemorrhage, but the effect was insufficient to improve the rate of survival. Mortality of first spontaneous bacterial peritonitis was 18%. These data suggest that the mortality of major complications of liver cirrhosis has considerably decreased during the last two decades, while there was no remarkable improvement in long-term survival. More efficient management of etiologic factors would be required. Korean Academy of Medical Sciences 2003-12 /pmc/articles/PMC3055146/ /pubmed/14676440 Text en |
spellingShingle | Research Article Kim, Young Sun Um, Soon Ho Ryu, Ho Sang Lee, Jung Bok Lee, Jae Won Park, Dong Kyu Kim, Yong Sik Jin, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Lee, Sang Woo Choi, Jai Hyun Kim, Chang Duck Hyun, Jin Hai The prognosis of liver cirrhosis in recent years in Korea. |
title | The prognosis of liver cirrhosis in recent years in Korea. |
title_full | The prognosis of liver cirrhosis in recent years in Korea. |
title_fullStr | The prognosis of liver cirrhosis in recent years in Korea. |
title_full_unstemmed | The prognosis of liver cirrhosis in recent years in Korea. |
title_short | The prognosis of liver cirrhosis in recent years in Korea. |
title_sort | prognosis of liver cirrhosis in recent years in korea. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055146/ https://www.ncbi.nlm.nih.gov/pubmed/14676440 |
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