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Centrilobular emphysema combined with pulmonary fibrosis results in improved survival

BACKGROUND: We hypothesized that, in patients with pulmonary fibrosis combined with emphysema, clinical characteristics and outcomes may differ from patients with pulmonary fibrosis without emphysema. We identified 102 patients who met established criteria for pulmonary fibrosis. The amount of emphy...

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Autores principales: Todd, Nevins W, Jeudy, Jean, Lavania, Sachin, Franks, Teri J, Galvin, Jeffrey R, Deepak, Janaki, Britt, Edward J, Atamas, Sergei P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055815/
https://www.ncbi.nlm.nih.gov/pubmed/21324139
http://dx.doi.org/10.1186/1755-1536-4-6
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author Todd, Nevins W
Jeudy, Jean
Lavania, Sachin
Franks, Teri J
Galvin, Jeffrey R
Deepak, Janaki
Britt, Edward J
Atamas, Sergei P
author_facet Todd, Nevins W
Jeudy, Jean
Lavania, Sachin
Franks, Teri J
Galvin, Jeffrey R
Deepak, Janaki
Britt, Edward J
Atamas, Sergei P
author_sort Todd, Nevins W
collection PubMed
description BACKGROUND: We hypothesized that, in patients with pulmonary fibrosis combined with emphysema, clinical characteristics and outcomes may differ from patients with pulmonary fibrosis without emphysema. We identified 102 patients who met established criteria for pulmonary fibrosis. The amount of emphysema (numerical score) and type of emphysema (centrilobular, paraseptal, or mixed) were characterized in each patient. Clinical characteristics, pulmonary function tests and patient survival were analysed. RESULTS: Based on the numerical emphysema score, patients were classified into those having no emphysema (n = 48), trivial emphysema (n = 26) or advanced emphysema (n = 28). Patients with advanced emphysema had a significantly higher amount of smoking in pack/years than patients with no emphysema or trivial emphysema (P < 0.0001). Median survival [1st, 3rd quartiles] of patients with advanced emphysema was 63 [36, 82] months compared to 29 [18, 49] months in patients without emphysema and 32 [19, 48] months in patients with trivial emphysema (P < 0.001). Median forced vital capacity (FVC) and total lung capacity (TLC) were higher in the advanced emphysema group compared to patients with no emphysema (P < 0.01 and P < 0.001, respectively), whereas median DL(CO )did not differ among groups and was overall low. Within the advanced emphysema group (n = 28), further characterization of the type of emphysema was performed and, within these subgroups of patients, survival was 75 [58, 85] months for patients with centrilobular emphysema, 75 [48, 85] months for patients with mixed centrilobular/paraseptal emphysema, and 24 [22, 35] months for patients with paraseptal emphysema (P < 0.01). Patients with advanced paraseptal emphysema had similar survival times to patients without emphysema. CONCLUSIONS: Patients with pulmonary fibrosis combined with advanced centrilobular or mixed emphysema have an improved survival compared with patients with pulmonary fibrosis without emphysema, with trivial emphysema or with advanced paraseptal emphysema.
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spelling pubmed-30558152011-03-12 Centrilobular emphysema combined with pulmonary fibrosis results in improved survival Todd, Nevins W Jeudy, Jean Lavania, Sachin Franks, Teri J Galvin, Jeffrey R Deepak, Janaki Britt, Edward J Atamas, Sergei P Fibrogenesis Tissue Repair Research BACKGROUND: We hypothesized that, in patients with pulmonary fibrosis combined with emphysema, clinical characteristics and outcomes may differ from patients with pulmonary fibrosis without emphysema. We identified 102 patients who met established criteria for pulmonary fibrosis. The amount of emphysema (numerical score) and type of emphysema (centrilobular, paraseptal, or mixed) were characterized in each patient. Clinical characteristics, pulmonary function tests and patient survival were analysed. RESULTS: Based on the numerical emphysema score, patients were classified into those having no emphysema (n = 48), trivial emphysema (n = 26) or advanced emphysema (n = 28). Patients with advanced emphysema had a significantly higher amount of smoking in pack/years than patients with no emphysema or trivial emphysema (P < 0.0001). Median survival [1st, 3rd quartiles] of patients with advanced emphysema was 63 [36, 82] months compared to 29 [18, 49] months in patients without emphysema and 32 [19, 48] months in patients with trivial emphysema (P < 0.001). Median forced vital capacity (FVC) and total lung capacity (TLC) were higher in the advanced emphysema group compared to patients with no emphysema (P < 0.01 and P < 0.001, respectively), whereas median DL(CO )did not differ among groups and was overall low. Within the advanced emphysema group (n = 28), further characterization of the type of emphysema was performed and, within these subgroups of patients, survival was 75 [58, 85] months for patients with centrilobular emphysema, 75 [48, 85] months for patients with mixed centrilobular/paraseptal emphysema, and 24 [22, 35] months for patients with paraseptal emphysema (P < 0.01). Patients with advanced paraseptal emphysema had similar survival times to patients without emphysema. CONCLUSIONS: Patients with pulmonary fibrosis combined with advanced centrilobular or mixed emphysema have an improved survival compared with patients with pulmonary fibrosis without emphysema, with trivial emphysema or with advanced paraseptal emphysema. BioMed Central 2011-02-15 /pmc/articles/PMC3055815/ /pubmed/21324139 http://dx.doi.org/10.1186/1755-1536-4-6 Text en Copyright ©2011 Todd et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Todd, Nevins W
Jeudy, Jean
Lavania, Sachin
Franks, Teri J
Galvin, Jeffrey R
Deepak, Janaki
Britt, Edward J
Atamas, Sergei P
Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title_full Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title_fullStr Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title_full_unstemmed Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title_short Centrilobular emphysema combined with pulmonary fibrosis results in improved survival
title_sort centrilobular emphysema combined with pulmonary fibrosis results in improved survival
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055815/
https://www.ncbi.nlm.nih.gov/pubmed/21324139
http://dx.doi.org/10.1186/1755-1536-4-6
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