BMP-12 Treatment of Adult Mesenchymal Stem Cells In Vitro Augments Tendon-Like Tissue Formation and Defect Repair In Vivo

We characterized the differentiation of rat bone marrow-derived mesenchymal stem cells (BM-MSCs) into tenocyte-like cells in response to bone morphogenetic protein-12 (BMP-12). BM-MSCs were prepared from Sprague-Dawley rats and cultured as monolayers. Recombinant BMP-12 treatment (10 ng/ml) of BM-MS...

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Detalles Bibliográficos
Autores principales: Lee, Jonathan Y., Zhou, Zuping, Taub, Peter J., Ramcharan, Melissa, Li, Yonghui, Akinbiyi, Takintope, Maharam, Edward R., Leong, Daniel J., Laudier, Damien M., Ruike, Takuya, Torina, Phillip J., Zaidi, Mone, Majeska, Robert J., Schaffler, Mitchell B., Flatow, Evan L., Sun, Hui B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055887/
https://www.ncbi.nlm.nih.gov/pubmed/21412429
http://dx.doi.org/10.1371/journal.pone.0017531

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