Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process

Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission...

Descripción completa

Detalles Bibliográficos
Autores principales: Thakur, Garima, Micic, Miodrag, Yang, Yuehai, Li, Wenzhi, Movia, Dania, Giordani, Silvia, Zhang, Hongzhou, Leblanc, Roger M.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056432/
https://www.ncbi.nlm.nih.gov/pubmed/21423556
http://dx.doi.org/10.4061/2011/502386
_version_ 1782200210014863360
author Thakur, Garima
Micic, Miodrag
Yang, Yuehai
Li, Wenzhi
Movia, Dania
Giordani, Silvia
Zhang, Hongzhou
Leblanc, Roger M.
author_facet Thakur, Garima
Micic, Miodrag
Yang, Yuehai
Li, Wenzhi
Movia, Dania
Giordani, Silvia
Zhang, Hongzhou
Leblanc, Roger M.
author_sort Thakur, Garima
collection PubMed
description Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
format Text
id pubmed-3056432
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher SAGE-Hindawi Access to Research
record_format MEDLINE/PubMed
spelling pubmed-30564322011-03-21 Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process Thakur, Garima Micic, Miodrag Yang, Yuehai Li, Wenzhi Movia, Dania Giordani, Silvia Zhang, Hongzhou Leblanc, Roger M. Int J Alzheimers Dis Research Article Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs. SAGE-Hindawi Access to Research 2011-03-02 /pmc/articles/PMC3056432/ /pubmed/21423556 http://dx.doi.org/10.4061/2011/502386 Text en Copyright © 2011 Garima Thakur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Thakur, Garima
Micic, Miodrag
Yang, Yuehai
Li, Wenzhi
Movia, Dania
Giordani, Silvia
Zhang, Hongzhou
Leblanc, Roger M.
Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title_full Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title_fullStr Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title_full_unstemmed Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title_short Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
title_sort conjugated quantum dots inhibit the amyloid β (1–42) fibrillation process
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056432/
https://www.ncbi.nlm.nih.gov/pubmed/21423556
http://dx.doi.org/10.4061/2011/502386
work_keys_str_mv AT thakurgarima conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT micicmiodrag conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT yangyuehai conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT liwenzhi conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT moviadania conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT giordanisilvia conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT zhanghongzhou conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess
AT leblancrogerm conjugatedquantumdotsinhibittheamyloidb142fibrillationprocess

Ejemplares similares