TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains

We report that NTRK2, the gene encoding for the TrkB receptor, can regulate APP metabolism, specifically AICD levels. Using the human neuroblastoma cell line SH-SY5Y, we characterized the effect of three TrkB isoforms (FL, SHC, T) on APP metabolism by knockdown and overexpression. We found that TrkB...

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Detalles Bibliográficos
Autores principales: Ansaloni, Sara, Leung, Brian P., Sebastian, Neeraj P., Samudralwar, Rohini, Gadaleta, Mariana, Saunders, Aleister J.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056454/
https://www.ncbi.nlm.nih.gov/pubmed/21423675
http://dx.doi.org/10.4061/2011/729382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056454/
https://www.ncbi.nlm.nih.gov/pubmed/21423675
http://dx.doi.org/10.4061/2011/729382

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