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Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome
Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer US
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056994/ https://www.ncbi.nlm.nih.gov/pubmed/21475729 http://dx.doi.org/10.1007/s11689-010-9070-3 |
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author | Stoddard, Joel Beckett, Laurel Simon, Tony J. |
author_facet | Stoddard, Joel Beckett, Laurel Simon, Tony J. |
author_sort | Stoddard, Joel |
collection | PubMed |
description | Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue × flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. |
format | Text |
id | pubmed-3056994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-30569942011-04-05 Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome Stoddard, Joel Beckett, Laurel Simon, Tony J. J Neurodev Disord Article Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue × flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. Springer US 2010-12-23 /pmc/articles/PMC3056994/ /pubmed/21475729 http://dx.doi.org/10.1007/s11689-010-9070-3 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Stoddard, Joel Beckett, Laurel Simon, Tony J. Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title | Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title_full | Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title_fullStr | Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title_full_unstemmed | Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title_short | Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
title_sort | atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056994/ https://www.ncbi.nlm.nih.gov/pubmed/21475729 http://dx.doi.org/10.1007/s11689-010-9070-3 |
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