Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6))...

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Detalles Bibliográficos
Autor principal: Jankowski, Maciej
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057024/
https://www.ncbi.nlm.nih.gov/pubmed/21423677
http://dx.doi.org/10.4061/2011/194857
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author Jankowski, Maciej
author_facet Jankowski, Maciej
author_sort Jankowski, Maciej
collection PubMed
description Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
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spelling pubmed-30570242011-03-21 Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target Jankowski, Maciej Enzyme Res Review Article Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed. SAGE-Hindawi Access to Research 2011-03-08 /pmc/articles/PMC3057024/ /pubmed/21423677 http://dx.doi.org/10.4061/2011/194857 Text en Copyright © 2011 Maciej Jankowski. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jankowski, Maciej
Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title_full Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title_fullStr Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title_full_unstemmed Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title_short Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
title_sort autotaxin: its role in biology of melanoma cells and as a pharmacological target
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057024/
https://www.ncbi.nlm.nih.gov/pubmed/21423677
http://dx.doi.org/10.4061/2011/194857
work_keys_str_mv AT jankowskimaciej autotaxinitsroleinbiologyofmelanomacellsandasapharmacologicaltarget

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