The Roles of ADAMs Family Proteinases in Skin Diseases

A disintegrin and metalloproteinases (ADAMs) are members of a new gene family of transmembrane and secreted proteins, which belong to the zinc proteinase superfamily. These molecules are involved in various biological events such as cell adhesion, cell fusion, cell migration, membrane protein sheddi...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Masakazu, Hearing, Vincent J.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057028/
https://www.ncbi.nlm.nih.gov/pubmed/21423681
http://dx.doi.org/10.4061/2011/482498
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author Kawaguchi, Masakazu
Hearing, Vincent J.
author_facet Kawaguchi, Masakazu
Hearing, Vincent J.
author_sort Kawaguchi, Masakazu
collection PubMed
description A disintegrin and metalloproteinases (ADAMs) are members of a new gene family of transmembrane and secreted proteins, which belong to the zinc proteinase superfamily. These molecules are involved in various biological events such as cell adhesion, cell fusion, cell migration, membrane protein shedding, and proteolysis. Growing evidence now attests to the potential involvement of ADAMs proteinases in diverse processes such as skin wound healing, inflammation, pigmentation, tumor development, cell proliferation, and metastasis. This paper focuses on the roles of ADAMs proteinases in a wide variety of skin diseases.
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spelling pubmed-30570282011-03-21 The Roles of ADAMs Family Proteinases in Skin Diseases Kawaguchi, Masakazu Hearing, Vincent J. Enzyme Res Review Article A disintegrin and metalloproteinases (ADAMs) are members of a new gene family of transmembrane and secreted proteins, which belong to the zinc proteinase superfamily. These molecules are involved in various biological events such as cell adhesion, cell fusion, cell migration, membrane protein shedding, and proteolysis. Growing evidence now attests to the potential involvement of ADAMs proteinases in diverse processes such as skin wound healing, inflammation, pigmentation, tumor development, cell proliferation, and metastasis. This paper focuses on the roles of ADAMs proteinases in a wide variety of skin diseases. SAGE-Hindawi Access to Research 2011-03-08 /pmc/articles/PMC3057028/ /pubmed/21423681 http://dx.doi.org/10.4061/2011/482498 Text en Copyright © 2011 M. Kawaguchi and V. J. Hearing. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kawaguchi, Masakazu
Hearing, Vincent J.
The Roles of ADAMs Family Proteinases in Skin Diseases
title The Roles of ADAMs Family Proteinases in Skin Diseases
title_full The Roles of ADAMs Family Proteinases in Skin Diseases
title_fullStr The Roles of ADAMs Family Proteinases in Skin Diseases
title_full_unstemmed The Roles of ADAMs Family Proteinases in Skin Diseases
title_short The Roles of ADAMs Family Proteinases in Skin Diseases
title_sort roles of adams family proteinases in skin diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057028/
https://www.ncbi.nlm.nih.gov/pubmed/21423681
http://dx.doi.org/10.4061/2011/482498
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