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Nuclear import of an intact preassembled proteasome particle

The 26S proteasome is a conserved 2.5 MDa protein degradation machine that localizes to different cellular compartments, including the nucleus. Little is known about the specific targeting mechanisms of proteasomes in eukaryotic cells. We used a cell-free nuclear reconstitution system to test for nu...

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Detalles Bibliográficos
Autores principales: Savulescu, Anca F., Shorer, Hagai, Kleifeld, Oded, Cohen, Ilana, Gruber, Rita, Glickman, Michael H., Harel, Amnon
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057711/
https://www.ncbi.nlm.nih.gov/pubmed/21289101
http://dx.doi.org/10.1091/mbc.E10-07-0595