Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

Sec14-superfamily proteins integrate the lipid metabolome with phosphoinositide synthesis and signaling via primed presentation of phosphatidylinositol (PtdIns) to PtdIns kinases. Sec14 action as a PtdIns-presentation scaffold requires heterotypic exchange of phosphatidylcholine (PtdCho) for PtdIns,...

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Detalles Bibliográficos
Autores principales: Schaaf, Gabriel, Dynowski, Marek, Mousley, Carl J., Shah, Sweety D., Yuan, Peihua, Winklbauer, Eva M., de Campos, Marília K. F., Trettin, Kyle, Quinones, Mary-Chely, Smirnova, Tatyana I., Yanagisawa, Lora L., Ortlund, Eric A., Bankaitis, Vytas A.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057712/
https://www.ncbi.nlm.nih.gov/pubmed/21248202
http://dx.doi.org/10.1091/mbc.E10-11-0903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057712/
https://www.ncbi.nlm.nih.gov/pubmed/21248202
http://dx.doi.org/10.1091/mbc.E10-11-0903

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