Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease

BACKGROUND: The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown but hypotheses about disease mechanisms include oxidative stress, defective axonal transport, mitochondrial dysfunction and disrupted RNA processing. Whereas familial ALS is well represented by transgenic mutant...

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Detalles Bibliográficos
Autores principales: Palmisano, Ralf, Golfi, Panagiota, Heimann, Peter, Shaw, Christopher, Troakes, Claire, Schmitt-John, Thomas, Bartsch, Jörg W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058068/
https://www.ncbi.nlm.nih.gov/pubmed/21385376
http://dx.doi.org/10.1186/1471-2202-12-24

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