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Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China
Human adenovirus (HAdV) is a causative agent of acute respiratory disease, which is prevalent throughout the world. Recently there are some reports which found that the HAdV-3 and HAdV-5 genomes were very stable across 50 years of time and space. But more and more recombinant genomes have been ident...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058094/ https://www.ncbi.nlm.nih.gov/pubmed/21371333 http://dx.doi.org/10.1186/1743-422X-8-91 |
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author | Su, Xiaobo Tian, Xingui Zhang, Qiwei Li, Haitao Li, Xiao Sheng, Huiying Wang, Youshao Wu, Houbo Zhou, Rong |
author_facet | Su, Xiaobo Tian, Xingui Zhang, Qiwei Li, Haitao Li, Xiao Sheng, Huiying Wang, Youshao Wu, Houbo Zhou, Rong |
author_sort | Su, Xiaobo |
collection | PubMed |
description | Human adenovirus (HAdV) is a causative agent of acute respiratory disease, which is prevalent throughout the world. Recently there are some reports which found that the HAdV-3 and HAdV-5 genomes were very stable across 50 years of time and space. But more and more recombinant genomes have been identified in emergent HAdV pathogens and it is a pathway for the molecular evolution of types. In our paper, we found a HAdV-7 GZ07 strain isolated from a child with acute respiratory disease, whose genome was E3-partial deleted. The whole genome was 32442 bp with 2864 bp deleted in E3 region and was annotated in detail (GenBank: HQ659699). The growth character was the same as that of another HAdV-7 wild strain which had no gene deletion. By comparison with E3 regions of the other HAdV-B, we found that only left-end two proteins were remained: 12.1 kDa glycoprotein and 16.1 kDa protein. E3 MHC class I antigen-binding glycoprotein, hypothetical 20.6 kDa protein, 20.6 kDa protein, 7.7 kDa protein., 10.3 kDa protein, 14.9 kDa protein and E3 14.7 kDa protein were all missing. It is the first report about E3 deletion in human adenovirus, which suggests that E3 region is also a possible recombination region in adenovirus molecular evolution. |
format | Text |
id | pubmed-3058094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30580942011-03-16 Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China Su, Xiaobo Tian, Xingui Zhang, Qiwei Li, Haitao Li, Xiao Sheng, Huiying Wang, Youshao Wu, Houbo Zhou, Rong Virol J Short Report Human adenovirus (HAdV) is a causative agent of acute respiratory disease, which is prevalent throughout the world. Recently there are some reports which found that the HAdV-3 and HAdV-5 genomes were very stable across 50 years of time and space. But more and more recombinant genomes have been identified in emergent HAdV pathogens and it is a pathway for the molecular evolution of types. In our paper, we found a HAdV-7 GZ07 strain isolated from a child with acute respiratory disease, whose genome was E3-partial deleted. The whole genome was 32442 bp with 2864 bp deleted in E3 region and was annotated in detail (GenBank: HQ659699). The growth character was the same as that of another HAdV-7 wild strain which had no gene deletion. By comparison with E3 regions of the other HAdV-B, we found that only left-end two proteins were remained: 12.1 kDa glycoprotein and 16.1 kDa protein. E3 MHC class I antigen-binding glycoprotein, hypothetical 20.6 kDa protein, 20.6 kDa protein, 7.7 kDa protein., 10.3 kDa protein, 14.9 kDa protein and E3 14.7 kDa protein were all missing. It is the first report about E3 deletion in human adenovirus, which suggests that E3 region is also a possible recombination region in adenovirus molecular evolution. BioMed Central 2011-03-04 /pmc/articles/PMC3058094/ /pubmed/21371333 http://dx.doi.org/10.1186/1743-422X-8-91 Text en Copyright ©2011 Su et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Su, Xiaobo Tian, Xingui Zhang, Qiwei Li, Haitao Li, Xiao Sheng, Huiying Wang, Youshao Wu, Houbo Zhou, Rong Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title | Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title_full | Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title_fullStr | Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title_full_unstemmed | Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title_short | Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China |
title_sort | complete genome analysis of a novel e3-partial-deleted human adenovirus type 7 strain isolated in southern china |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058094/ https://www.ncbi.nlm.nih.gov/pubmed/21371333 http://dx.doi.org/10.1186/1743-422X-8-91 |
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