Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of IL-1β and IL-18. While wild type Salmonella typhimurium infection is lethal to mice, a strain that persistently expresses flagellin was cleared by the cytosolic flagellin detection pathway via NLR...

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Detalles Bibliográficos
Autores principales: Miao, Edward A., Leaf, Irina A., Treuting, Piper M., Mao, Dat P., Dors, Monica, Sarkar, Anasuya, Warren, Sarah E., Wewers, Mark D., Aderem, Alan
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058225/
https://www.ncbi.nlm.nih.gov/pubmed/21057511
http://dx.doi.org/10.1038/ni.1960

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