A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor

[Image: see text] Noroviruses are the major cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a 3C cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional proteins. Here we describe the X-ray structure of the Southampton norovirus 3C...

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Detalles Bibliográficos
Autores principales: Hussey, Robert J., Coates, Leighton, Gill, Raj S., Erskine, Peter T., Coker, Shu-Fen, Mitchell, Ed, Cooper, Jonathan B., Wood, Steve, Broadbridge, Robert, Clarke, Ian N., Lambden, Paul R., Shoolingin-Jordan, Peter M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058531/
https://www.ncbi.nlm.nih.gov/pubmed/21128685
http://dx.doi.org/10.1021/bi1008497

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