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Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers
AIMS: Hypertrophic cardiomyopathy (HCM) is a frequent cause of sudden cardiac death (SCD) due to exercise-related ventricular arrhythmias (ERVA); however the pathological substrate is uncertain. The aim was to determine the prevalence of ERVA and their relation with fibrosis as determined by cardiac...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Bohn Stafleu van Loghum
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058538/ https://www.ncbi.nlm.nih.gov/pubmed/21475680 http://dx.doi.org/10.1007/s12471-011-0090-8 |
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author | van Rijsingen, I. A. W. Bekkers, S. C. A. M. Schalla, S. Hermans-van Ast, J. F. Snoep, G. Alzand, B. S. N. Arens, Y. H. J. M. van den Wijngaard, A. Crijns, H. J. G. M. Pinto, Y. M. |
author_facet | van Rijsingen, I. A. W. Bekkers, S. C. A. M. Schalla, S. Hermans-van Ast, J. F. Snoep, G. Alzand, B. S. N. Arens, Y. H. J. M. van den Wijngaard, A. Crijns, H. J. G. M. Pinto, Y. M. |
author_sort | van Rijsingen, I. A. W. |
collection | PubMed |
description | AIMS: Hypertrophic cardiomyopathy (HCM) is a frequent cause of sudden cardiac death (SCD) due to exercise-related ventricular arrhythmias (ERVA); however the pathological substrate is uncertain. The aim was to determine the prevalence of ERVA and their relation with fibrosis as determined by cardiac magnetic resonance imaging (CMR) in carriers of an HCM causing mutation. METHODS: We studied the prevalence and origin of ERVA and related these with fibrosis on CMR in a population of 31 HCM mutation carriers. RESULTS: ERVA occurred in seven patients (23%) who all showed evidence of fibrosis (100% ERVA(+) vs. 58% ERVA(-), p = 0.04). No ventricular tachycardia or ventricular fibrillation occurred. In patients with ERVA, the extent of fibrosis was significantly larger (8 ± 4% vs. 3 ± 4%, p = 0.02). ERVA originated from areas with a high extent of fibrosis or regions directly adjacent to these areas. CONCLUSIONS: ERVA in HCM mutation carriers arose from the area of fibrosis detected by CMR; ERVA seems closely related to cardiac fibrosis. Fibrosis as detected by CMR should be evaluated as an additional risk factor to further delineate risk of SCD in carriers of an HCM causing mutation. |
format | Text |
id | pubmed-3058538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bohn Stafleu van Loghum |
record_format | MEDLINE/PubMed |
spelling | pubmed-30585382011-04-05 Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers van Rijsingen, I. A. W. Bekkers, S. C. A. M. Schalla, S. Hermans-van Ast, J. F. Snoep, G. Alzand, B. S. N. Arens, Y. H. J. M. van den Wijngaard, A. Crijns, H. J. G. M. Pinto, Y. M. Neth Heart J Original Article AIMS: Hypertrophic cardiomyopathy (HCM) is a frequent cause of sudden cardiac death (SCD) due to exercise-related ventricular arrhythmias (ERVA); however the pathological substrate is uncertain. The aim was to determine the prevalence of ERVA and their relation with fibrosis as determined by cardiac magnetic resonance imaging (CMR) in carriers of an HCM causing mutation. METHODS: We studied the prevalence and origin of ERVA and related these with fibrosis on CMR in a population of 31 HCM mutation carriers. RESULTS: ERVA occurred in seven patients (23%) who all showed evidence of fibrosis (100% ERVA(+) vs. 58% ERVA(-), p = 0.04). No ventricular tachycardia or ventricular fibrillation occurred. In patients with ERVA, the extent of fibrosis was significantly larger (8 ± 4% vs. 3 ± 4%, p = 0.02). ERVA originated from areas with a high extent of fibrosis or regions directly adjacent to these areas. CONCLUSIONS: ERVA in HCM mutation carriers arose from the area of fibrosis detected by CMR; ERVA seems closely related to cardiac fibrosis. Fibrosis as detected by CMR should be evaluated as an additional risk factor to further delineate risk of SCD in carriers of an HCM causing mutation. Bohn Stafleu van Loghum 2011-02-17 2011-04 /pmc/articles/PMC3058538/ /pubmed/21475680 http://dx.doi.org/10.1007/s12471-011-0090-8 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Article van Rijsingen, I. A. W. Bekkers, S. C. A. M. Schalla, S. Hermans-van Ast, J. F. Snoep, G. Alzand, B. S. N. Arens, Y. H. J. M. van den Wijngaard, A. Crijns, H. J. G. M. Pinto, Y. M. Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title | Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title_full | Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title_fullStr | Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title_full_unstemmed | Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title_short | Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
title_sort | exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058538/ https://www.ncbi.nlm.nih.gov/pubmed/21475680 http://dx.doi.org/10.1007/s12471-011-0090-8 |
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