Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

Pancreatic cancer is a very aggressive disease characterized by a marked desmoplasia with a predominant Th2 (GATA-3(+)) over Th1 (T-bet(+)) lymphoid infiltrate. We found that the ratio of GATA-3(+)/T-bet(+) tumor-infiltrating lymphoid cells is an independent predictive marker of patient survival. Pa...

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Detalles Bibliográficos
Autores principales: De Monte, Lucia, Reni, Michele, Tassi, Elena, Clavenna, Daniela, Papa, Ilenia, Recalde, Helios, Braga, Marco, Di Carlo, Valerio, Doglioni, Claudio, Protti, Maria Pia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058573/
https://www.ncbi.nlm.nih.gov/pubmed/21339327
http://dx.doi.org/10.1084/jem.20101876

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