Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?

The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent st...

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Autor principal: Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058865/
https://www.ncbi.nlm.nih.gov/pubmed/21311101
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author Jeang, Kuan-Teh
author_facet Jeang, Kuan-Teh
author_sort Jeang, Kuan-Teh
collection PubMed
description The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent studies have shown that HTLV-1 transformed cells show deregulated expression of cellular microRNAs (miRNAs). Here we discuss the possibility that early ATL cells are Tax-oncogeneaddicted while late ATL cells are oncogenic microRNA (oncomiR) – addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached.
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spelling pubmed-30588652011-03-16 Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction? Jeang, Kuan-Teh Oncotarget Research Perspectives The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent studies have shown that HTLV-1 transformed cells show deregulated expression of cellular microRNAs (miRNAs). Here we discuss the possibility that early ATL cells are Tax-oncogeneaddicted while late ATL cells are oncogenic microRNA (oncomiR) – addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached. Impact Journals LLC 2010-10-01 /pmc/articles/PMC3058865/ /pubmed/21311101 Text en Copyright: © 2010 Jeang http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Jeang, Kuan-Teh
Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title_full Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title_fullStr Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title_full_unstemmed Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title_short Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
title_sort human t cell leukemia virus type 1 (htlv-1) and oncogene or oncomir addiction?
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058865/
https://www.ncbi.nlm.nih.gov/pubmed/21311101
work_keys_str_mv AT jeangkuanteh humantcellleukemiavirustype1htlv1andoncogeneoroncomiraddiction

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