5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver

Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed insulin resistance in the liver, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished anti-diabetic effects of mCPP (a 5-HT(2C)R agonist) while such effects were re...

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Autores principales: Xu, Yong, Berglund, Eric D., Sohn, Jong-Woo, Holland, William L., Chuang, Jen-Chieh, Fukuda, Makoto, Rossi, Jari, Williams, Kevin W., Jones, Juli E., Zigman, Jeffrey M., Lowell, Bradford B., Scherer, Philipp E., Elmquist, Joel K.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059249/
https://www.ncbi.nlm.nih.gov/pubmed/21037584
http://dx.doi.org/10.1038/nn.2664
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author Xu, Yong
Berglund, Eric D.
Sohn, Jong-Woo
Holland, William L.
Chuang, Jen-Chieh
Fukuda, Makoto
Rossi, Jari
Williams, Kevin W.
Jones, Juli E.
Zigman, Jeffrey M.
Lowell, Bradford B.
Scherer, Philipp E.
Elmquist, Joel K.
author_facet Xu, Yong
Berglund, Eric D.
Sohn, Jong-Woo
Holland, William L.
Chuang, Jen-Chieh
Fukuda, Makoto
Rossi, Jari
Williams, Kevin W.
Jones, Juli E.
Zigman, Jeffrey M.
Lowell, Bradford B.
Scherer, Philipp E.
Elmquist, Joel K.
author_sort Xu, Yong
collection PubMed
description Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed insulin resistance in the liver, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished anti-diabetic effects of mCPP (a 5-HT(2C)R agonist) while such effects were restored in mice with 5-HT(2C)Rs re-expressed in POMC neurons. Our findings demonstrated that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.
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spelling pubmed-30592492011-06-01 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver Xu, Yong Berglund, Eric D. Sohn, Jong-Woo Holland, William L. Chuang, Jen-Chieh Fukuda, Makoto Rossi, Jari Williams, Kevin W. Jones, Juli E. Zigman, Jeffrey M. Lowell, Bradford B. Scherer, Philipp E. Elmquist, Joel K. Nat Neurosci Article Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed insulin resistance in the liver, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished anti-diabetic effects of mCPP (a 5-HT(2C)R agonist) while such effects were restored in mice with 5-HT(2C)Rs re-expressed in POMC neurons. Our findings demonstrated that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver. 2010-10-31 2010-12 /pmc/articles/PMC3059249/ /pubmed/21037584 http://dx.doi.org/10.1038/nn.2664 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Xu, Yong
Berglund, Eric D.
Sohn, Jong-Woo
Holland, William L.
Chuang, Jen-Chieh
Fukuda, Makoto
Rossi, Jari
Williams, Kevin W.
Jones, Juli E.
Zigman, Jeffrey M.
Lowell, Bradford B.
Scherer, Philipp E.
Elmquist, Joel K.
5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title_full 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title_fullStr 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title_full_unstemmed 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title_short 5-HT(2C)Rs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver
title_sort 5-ht(2c)rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059249/
https://www.ncbi.nlm.nih.gov/pubmed/21037584
http://dx.doi.org/10.1038/nn.2664
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