Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus

Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that can be found in almost all postnatal organs and tissues. The main functional characteristics of MSCs are their immunomodulatory ability, capacity for self-renewal, and differentiation into mesodermal tissues. The ability of MSCs...

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Autores principales: Volarevic, Vladislav, Arsenijevic, Nebojsa, Lukic, Miodrag L, Stojkovic, Miodrag
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Concise Review: Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059410/
https://www.ncbi.nlm.nih.gov/pubmed/21280154
http://dx.doi.org/10.1002/stem.556
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author Volarevic, Vladislav
Arsenijevic, Nebojsa
Lukic, Miodrag L
Stojkovic, Miodrag
author_facet Volarevic, Vladislav
Arsenijevic, Nebojsa
Lukic, Miodrag L
Stojkovic, Miodrag
author_sort Volarevic, Vladislav
collection PubMed
description Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that can be found in almost all postnatal organs and tissues. The main functional characteristics of MSCs are their immunomodulatory ability, capacity for self-renewal, and differentiation into mesodermal tissues. The ability of MSCs to differentiate into several cell types, including muscle, brain, vascular, skin, cartilage, and bone cells, makes them attractive as therapeutic agents for a number of diseases including complications of diabetes mellitus. We review here the potential of MSCs as new therapeutic agents in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic polyneuropathy, diabetic retinopathy, and diabetic wounds. Also, in this review we discuss the current limitations for MSCs therapy in humans. Stem Cells 2011;29:5–10
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spelling pubmed-30594102011-03-25 Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus Volarevic, Vladislav Arsenijevic, Nebojsa Lukic, Miodrag L Stojkovic, Miodrag Stem Cells Concise Review: Regenerative Medicine Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that can be found in almost all postnatal organs and tissues. The main functional characteristics of MSCs are their immunomodulatory ability, capacity for self-renewal, and differentiation into mesodermal tissues. The ability of MSCs to differentiate into several cell types, including muscle, brain, vascular, skin, cartilage, and bone cells, makes them attractive as therapeutic agents for a number of diseases including complications of diabetes mellitus. We review here the potential of MSCs as new therapeutic agents in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic polyneuropathy, diabetic retinopathy, and diabetic wounds. Also, in this review we discuss the current limitations for MSCs therapy in humans. Stem Cells 2011;29:5–10 Wiley Subscription Services, Inc., A Wiley Company 2011-01 2010-11-09 /pmc/articles/PMC3059410/ /pubmed/21280154 http://dx.doi.org/10.1002/stem.556 Text en Copyright © 2010 AlphaMed Press http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Concise Review: Regenerative Medicine
Volarevic, Vladislav
Arsenijevic, Nebojsa
Lukic, Miodrag L
Stojkovic, Miodrag
Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title_full Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title_fullStr Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title_full_unstemmed Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title_short Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus
title_sort concise review: mesenchymal stem cell treatment of the complications of diabetes mellitus
topic Concise Review: Regenerative Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059410/
https://www.ncbi.nlm.nih.gov/pubmed/21280154
http://dx.doi.org/10.1002/stem.556
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AT stojkovicmiodrag concisereviewmesenchymalstemcelltreatmentofthecomplicationsofdiabetesmellitus

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