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Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats

The antidiabetic activity of Pongamia pinnata ( Family: Leguminosae) leaf extracts was investigated in alloxan-induced diabetic albino rats. A comparison was made between the action of different extracts of P. pinnata and a known antidiabetic drug glibenclamide (600 μg/kg b. wt.). An oral glucose to...

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Autores principales: Sikarwar, Mukesh S., Patil, M.B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059439/
https://www.ncbi.nlm.nih.gov/pubmed/21455444
http://dx.doi.org/10.4103/0974-7788.76780
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author Sikarwar, Mukesh S.
Patil, M.B.
author_facet Sikarwar, Mukesh S.
Patil, M.B.
author_sort Sikarwar, Mukesh S.
collection PubMed
description The antidiabetic activity of Pongamia pinnata ( Family: Leguminosae) leaf extracts was investigated in alloxan-induced diabetic albino rats. A comparison was made between the action of different extracts of P. pinnata and a known antidiabetic drug glibenclamide (600 μg/kg b. wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The petroleum ether, chloroform, alcohol and aqueous extracts of P. pinnata were obtained by simple maceration method and were subjected to standardization using pharmacognostical and phytochemical screening methods. Dose selection was made on the basis of acute oral toxicity study (50-5000 mg/kg b. w.) as per OECD guidelines. P. pinnata ethanolic extract (PPEE) and aqueous extract (PPAE) showed significant (P < 0.001) antidiabetic activity. In alloxan-induced model, blood glucose levels of these extracts on 7th day of the study were 155.83 ± 11.211mg/dl (PPEE) and 132.00 ± 4.955mg/dl (PPAE) in comparison of diabetic control (413.50 ± 4.752mg/dl) and chloroform extract (210.83 ± 14.912mg/dl). In glucose loaded rats, PPEE exhibited glucose level of 164.50 ± 6.350mg/dl after 30 min and 156.50 ± 4.089mg/dl after 90 min, whereas the levels in PPAE treated animals were 176 ± 3.724mg/dl after 30 min and 110.33 ± 6.687mg/dl after 90 min. These extracts also prevented body weight loss in diabetic rats. The drug has the potential to act as an antidiabetic drug.
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spelling pubmed-30594392011-03-31 Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats Sikarwar, Mukesh S. Patil, M.B. Int J Ayurveda Res Original Article The antidiabetic activity of Pongamia pinnata ( Family: Leguminosae) leaf extracts was investigated in alloxan-induced diabetic albino rats. A comparison was made between the action of different extracts of P. pinnata and a known antidiabetic drug glibenclamide (600 μg/kg b. wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The petroleum ether, chloroform, alcohol and aqueous extracts of P. pinnata were obtained by simple maceration method and were subjected to standardization using pharmacognostical and phytochemical screening methods. Dose selection was made on the basis of acute oral toxicity study (50-5000 mg/kg b. w.) as per OECD guidelines. P. pinnata ethanolic extract (PPEE) and aqueous extract (PPAE) showed significant (P < 0.001) antidiabetic activity. In alloxan-induced model, blood glucose levels of these extracts on 7th day of the study were 155.83 ± 11.211mg/dl (PPEE) and 132.00 ± 4.955mg/dl (PPAE) in comparison of diabetic control (413.50 ± 4.752mg/dl) and chloroform extract (210.83 ± 14.912mg/dl). In glucose loaded rats, PPEE exhibited glucose level of 164.50 ± 6.350mg/dl after 30 min and 156.50 ± 4.089mg/dl after 90 min, whereas the levels in PPAE treated animals were 176 ± 3.724mg/dl after 30 min and 110.33 ± 6.687mg/dl after 90 min. These extracts also prevented body weight loss in diabetic rats. The drug has the potential to act as an antidiabetic drug. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3059439/ /pubmed/21455444 http://dx.doi.org/10.4103/0974-7788.76780 Text en Copyright: © International Journal of Ayurveda Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sikarwar, Mukesh S.
Patil, M.B.
Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title_full Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title_fullStr Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title_full_unstemmed Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title_short Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats
title_sort antidiabetic activity of pongamia pinnata leaf extracts in alloxan-induced diabetic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059439/
https://www.ncbi.nlm.nih.gov/pubmed/21455444
http://dx.doi.org/10.4103/0974-7788.76780
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