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Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial
OBJECTIVES: The study was planned to evaluate the efficacy and safety of Livwin (polyherbal formulation) in acute viral hepatitis. MATERIALS AND METHODS: In this study, there were 29 patients in each group, receiving either Livwin (containing Ashwagandha, Arjuna, Bhumyamalaki, Daruharidra, Guduchi,...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059443/ https://www.ncbi.nlm.nih.gov/pubmed/21455448 http://dx.doi.org/10.4103/0974-7788.76784 |
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author | Keche, Yogendra Badar, Vandana Hardas, Mrunalini |
author_facet | Keche, Yogendra Badar, Vandana Hardas, Mrunalini |
author_sort | Keche, Yogendra |
collection | PubMed |
description | OBJECTIVES: The study was planned to evaluate the efficacy and safety of Livwin (polyherbal formulation) in acute viral hepatitis. MATERIALS AND METHODS: In this study, there were 29 patients in each group, receiving either Livwin (containing Ashwagandha, Arjuna, Bhumyamalaki, Daruharidra, Guduchi, Kutki and Punarnava) or placebo capsules containing lactose powder (500 mg). Both drugs were given orally two capsules two times a day for eight weeks followed by treatment free period of four weeks. Recovery of patients was assessed by noting symptomatic recovery and by measuring levels of serum bilirubin, serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase at baseline, 2, 4, 8 and 12 weeks. RESULTS: Significant earlier recovery of weakness was observed with Livwin as compared to placebo at 2, 4 and 8 weeks. Serum bilirubin and ALT was observed in normal range in significantly more number of patients with Livwin treatment as compared to placebo at 2, 4 and 8 weeks. AST was observed in normal range in significantly more number of patients with Livwin treatment as compared to placebo at 2 and 4 weeks. CONCLUSIONS: Livwin is found effective in uncomplicated patients of acute viral hepatitis. Epigastric pain and diarrhea were reported with Livwin treatment. |
format | Text |
id | pubmed-3059443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-30594432011-03-31 Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial Keche, Yogendra Badar, Vandana Hardas, Mrunalini Int J Ayurveda Res Original Article OBJECTIVES: The study was planned to evaluate the efficacy and safety of Livwin (polyherbal formulation) in acute viral hepatitis. MATERIALS AND METHODS: In this study, there were 29 patients in each group, receiving either Livwin (containing Ashwagandha, Arjuna, Bhumyamalaki, Daruharidra, Guduchi, Kutki and Punarnava) or placebo capsules containing lactose powder (500 mg). Both drugs were given orally two capsules two times a day for eight weeks followed by treatment free period of four weeks. Recovery of patients was assessed by noting symptomatic recovery and by measuring levels of serum bilirubin, serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase at baseline, 2, 4, 8 and 12 weeks. RESULTS: Significant earlier recovery of weakness was observed with Livwin as compared to placebo at 2, 4 and 8 weeks. Serum bilirubin and ALT was observed in normal range in significantly more number of patients with Livwin treatment as compared to placebo at 2, 4 and 8 weeks. AST was observed in normal range in significantly more number of patients with Livwin treatment as compared to placebo at 2 and 4 weeks. CONCLUSIONS: Livwin is found effective in uncomplicated patients of acute viral hepatitis. Epigastric pain and diarrhea were reported with Livwin treatment. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3059443/ /pubmed/21455448 http://dx.doi.org/10.4103/0974-7788.76784 Text en Copyright: © International Journal of Ayurveda Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Keche, Yogendra Badar, Vandana Hardas, Mrunalini Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title | Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title_full | Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title_fullStr | Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title_full_unstemmed | Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title_short | Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial |
title_sort | efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: a randomized double-blind placebo-controlled clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059443/ https://www.ncbi.nlm.nih.gov/pubmed/21455448 http://dx.doi.org/10.4103/0974-7788.76784 |
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