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Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis

Early-onset methamphetamine use increases the lifetime prevalence of methamphetamine dependence. An earlier onset of methamphetamine use leads to greater damage to the terminal ends of serotonin neurons, more reduction in serotonin transporter (5-HTT) density, and an increased propensity toward furt...

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Autores principales: Johnson, Bankole A., Elkashef, Ahmed M., Seneviratne, Chamindi, Ait-Daoud, Nassima, Kahn, Roberta C., Li, Shou-Hua, Bloch, Daniel A., Holmes, Tyson H., Wang, Xin-Qun, Jr., Francis J. Vocci, Li, Ming D.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059661/
https://www.ncbi.nlm.nih.gov/pubmed/21423453
http://dx.doi.org/10.3389/fpsyt.2010.00145
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author Johnson, Bankole A.
Elkashef, Ahmed M.
Seneviratne, Chamindi
Ait-Daoud, Nassima
Kahn, Roberta C.
Li, Shou-Hua
Bloch, Daniel A.
Holmes, Tyson H.
Wang, Xin-Qun
Jr., Francis J. Vocci
Li, Ming D.
author_facet Johnson, Bankole A.
Elkashef, Ahmed M.
Seneviratne, Chamindi
Ait-Daoud, Nassima
Kahn, Roberta C.
Li, Shou-Hua
Bloch, Daniel A.
Holmes, Tyson H.
Wang, Xin-Qun
Jr., Francis J. Vocci
Li, Ming D.
author_sort Johnson, Bankole A.
collection PubMed
description Early-onset methamphetamine use increases the lifetime prevalence of methamphetamine dependence. An earlier onset of methamphetamine use leads to greater damage to the terminal ends of serotonin neurons, more reduction in serotonin transporter (5-HTT) density, and an increased propensity toward further methamphetamine use. Because the 5-HTT-linked polymorphic region (5′-HTTLPR) within the promoter region of the 5-HTT gene leads to differential expression of the 5-HTT, we examined, for the first time, whether there is a differential association between the long (L) and short (S) alleles of the 5′-HTTLPR and the age of first methamphetamine use (AMU). The study included 120 methamphetamine-dependent adults of European descent. Diagnosis of methamphetamine dependence and AMU were collected using structured questionnaires, and the 5′-HTTLPR genotypes were determined using the polymerase chain reaction–restriction fragment length polymorphism method. Statistical analysis with the general linear model detected a significant interactive effect of 5′-HTTLPR genotypes (SS vs. L-carriers) and gender, associated with AMU (F = 3.99; p = 0.048). Further analysis of 5′-HTTLPR effects on AMU in males and females separately showed that the SS genotype compared with L-carriers had about two times greater risk of an earlier onset of methamphetamine use in men (hazard ratio = 1.839; 95% confidence interval = 1.042–3.246; p = 0.036) but not in women. Together, our findings in this preliminary study suggest a greater risk for earlier onset methamphetamine use associated with the SS genotype of the 5′-HTTLPR among methamphetamine-dependent Caucasian males.
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spelling pubmed-30596612011-03-21 Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis Johnson, Bankole A. Elkashef, Ahmed M. Seneviratne, Chamindi Ait-Daoud, Nassima Kahn, Roberta C. Li, Shou-Hua Bloch, Daniel A. Holmes, Tyson H. Wang, Xin-Qun Jr., Francis J. Vocci Li, Ming D. Front Psychiatry Psychiatry Early-onset methamphetamine use increases the lifetime prevalence of methamphetamine dependence. An earlier onset of methamphetamine use leads to greater damage to the terminal ends of serotonin neurons, more reduction in serotonin transporter (5-HTT) density, and an increased propensity toward further methamphetamine use. Because the 5-HTT-linked polymorphic region (5′-HTTLPR) within the promoter region of the 5-HTT gene leads to differential expression of the 5-HTT, we examined, for the first time, whether there is a differential association between the long (L) and short (S) alleles of the 5′-HTTLPR and the age of first methamphetamine use (AMU). The study included 120 methamphetamine-dependent adults of European descent. Diagnosis of methamphetamine dependence and AMU were collected using structured questionnaires, and the 5′-HTTLPR genotypes were determined using the polymerase chain reaction–restriction fragment length polymorphism method. Statistical analysis with the general linear model detected a significant interactive effect of 5′-HTTLPR genotypes (SS vs. L-carriers) and gender, associated with AMU (F = 3.99; p = 0.048). Further analysis of 5′-HTTLPR effects on AMU in males and females separately showed that the SS genotype compared with L-carriers had about two times greater risk of an earlier onset of methamphetamine use in men (hazard ratio = 1.839; 95% confidence interval = 1.042–3.246; p = 0.036) but not in women. Together, our findings in this preliminary study suggest a greater risk for earlier onset methamphetamine use associated with the SS genotype of the 5′-HTTLPR among methamphetamine-dependent Caucasian males. Frontiers Research Foundation 2010-11-01 /pmc/articles/PMC3059661/ /pubmed/21423453 http://dx.doi.org/10.3389/fpsyt.2010.00145 Text en Copyright © 2010 Johnson, Elkashef, Seneviratne, Ait-Daoud, Kahn, Li, Bloch, Holmes, Wang, Vocci Jr., Li and the Methamphetamine Study Group. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Psychiatry
Johnson, Bankole A.
Elkashef, Ahmed M.
Seneviratne, Chamindi
Ait-Daoud, Nassima
Kahn, Roberta C.
Li, Shou-Hua
Bloch, Daniel A.
Holmes, Tyson H.
Wang, Xin-Qun
Jr., Francis J. Vocci
Li, Ming D.
Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title_full Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title_fullStr Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title_full_unstemmed Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title_short Association between Genotype of the Serotonin Transporter-Linked Polymorphic Region of the Serotonin Transporter Gene and Age of Onset of Methamphetamine Use: a Preliminary Analysis
title_sort association between genotype of the serotonin transporter-linked polymorphic region of the serotonin transporter gene and age of onset of methamphetamine use: a preliminary analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059661/
https://www.ncbi.nlm.nih.gov/pubmed/21423453
http://dx.doi.org/10.3389/fpsyt.2010.00145
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