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Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses

It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N-methyl-d-aspartate (NMDA) receptors. In this review, we discuss the evidence for the presence of presynaptic NMDA receptors at cortical synapses and their possible role in the induc...

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Detalles Bibliográficos
Autores principales: Rodríguez-Moreno, Antonio, Banerjee, Abhishek, Paulsen, Ole
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059699/
https://www.ncbi.nlm.nih.gov/pubmed/21423504
http://dx.doi.org/10.3389/fnsyn.2010.00018
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author Rodríguez-Moreno, Antonio
Banerjee, Abhishek
Paulsen, Ole
author_facet Rodríguez-Moreno, Antonio
Banerjee, Abhishek
Paulsen, Ole
author_sort Rodríguez-Moreno, Antonio
collection PubMed
description It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N-methyl-d-aspartate (NMDA) receptors. In this review, we discuss the evidence for the presence of presynaptic NMDA receptors at cortical synapses and their possible role in the induction of t-LTD. Two basic models emerge for the induction of t-LTD at cortical synapses. In one model, coincident activation of presynaptic NMDA receptors and CB1 receptors mediates t-LTD. In a second model, CB1 receptors are not necessary, and the activation of presynaptic NMDA receptors alone appears to be sufficient for the induction of t-LTD.
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spelling pubmed-30596992011-03-21 Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses Rodríguez-Moreno, Antonio Banerjee, Abhishek Paulsen, Ole Front Synaptic Neurosci Neuroscience It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N-methyl-d-aspartate (NMDA) receptors. In this review, we discuss the evidence for the presence of presynaptic NMDA receptors at cortical synapses and their possible role in the induction of t-LTD. Two basic models emerge for the induction of t-LTD at cortical synapses. In one model, coincident activation of presynaptic NMDA receptors and CB1 receptors mediates t-LTD. In a second model, CB1 receptors are not necessary, and the activation of presynaptic NMDA receptors alone appears to be sufficient for the induction of t-LTD. Frontiers Research Foundation 2010-06-17 /pmc/articles/PMC3059699/ /pubmed/21423504 http://dx.doi.org/10.3389/fnsyn.2010.00018 Text en Copyright © 2010 Rodríguez-Moreno, Banerjee and Paulsen. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Rodríguez-Moreno, Antonio
Banerjee, Abhishek
Paulsen, Ole
Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title_full Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title_fullStr Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title_full_unstemmed Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title_short Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
title_sort presynaptic nmda receptors and spike timing-dependent depression at cortical synapses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059699/
https://www.ncbi.nlm.nih.gov/pubmed/21423504
http://dx.doi.org/10.3389/fnsyn.2010.00018
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