Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor, and its substrate AMPK, kinases that coordinate metabolism with cell growth. Lkb1 deletion caused increased haematopoietic stem cell (HSC)...

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Detalles Bibliográficos
Autores principales: Nakada, Daisuke, Saunders, Thomas L., Morrison, Sean J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059717/
https://www.ncbi.nlm.nih.gov/pubmed/21124450
http://dx.doi.org/10.1038/nature09571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059717/
https://www.ncbi.nlm.nih.gov/pubmed/21124450
http://dx.doi.org/10.1038/nature09571

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