Cargando…

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor, and its substrate AMPK, kinases that coordinate metabolism with cell growth. Lkb1 deletion caused increased haematopoietic stem cell (HSC)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakada, Daisuke, Saunders, Thomas L., Morrison, Sean J.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059717/ https://www.ncbi.nlm.nih.gov/pubmed/21124450 http://dx.doi.org/10.1038/nature09571

Ejemplares similares

Endothelial and perivascular cells maintain haematopoietic stem cells
por: Ding, Lei, et al.
Publicado: (2012)

Estrogen increases haematopoietic stem cell self-renewal in females and during pregnancy
por: Nakada, Daisuke, et al.
Publicado: (2014)

LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells
por: Gan, Boyi, et al.
Publicado: (2010)

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
por: Agathocleous, Michalis, et al.
Publicado: (2017)

Haematopoietic stem cells require a highly regulated protein synthesis rate
por: Signer, Robert A.J., et al.
Publicado: (2014)

The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
por: Lilly, Andrew J., et al.
Publicado: (2011)

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
por: Barbier-Torres, Lucía, et al.
Publicado: (2014)

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
por: Ding, Lei, et al.
Publicado: (2013)

Inflammation Regulates Haematopoietic Stem Cells and Their Niche
por: Ho, Nicole Pui-Yu, et al.
Publicado: (2022)

Nociceptive nerves regulate haematopoietic stem cell mobilization
por: Gao, Xin, et al.
Publicado: (2020)

Expansion of Haematopoietic Stem and Progenitor Cells: Paving the Way for Next-Generation Haematopoietic Stem Cell Transplantation
por: Bari, Sudipto, et al.
Publicado: (2019)

Role of Haematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphoma
por: Abeyakoon, Chathuri, et al.
Publicado: (2020)

Clonality in haematopoietic stem cell ageing
por: Terradas-Terradas, Maria, et al.
Publicado: (2020)

Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells
por: Mesbahi, Yashar, et al.
Publicado: (2022)

Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines
por: Philonenko, Elena S., et al.
Publicado: (2021)

LKB1 specifies neural crest cell fates through pyruvate-alanine cycling
por: Radu, Anca G., et al.
Publicado: (2019)

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1
por: He, Nanhai, et al.
Publicado: (2017)

BMP signalling differentially regulates distinct haematopoietic stem cell types
por: Crisan, Mihaela, et al.
Publicado: (2015)

Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells
por: Volpe, Giacomo, et al.
Publicado: (2015)

Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells
por: Burgess, Rebecca J., et al.
Publicado: (2022)

PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis
por: Gupta, Pallavi, et al.
Publicado: (2009)

In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
por: Renda, Maria Concetta, et al.
Publicado: (2009)

Haematopoietic Stem Cell Transplantation and the Price to Pay For
por: Maffulli, N.
Publicado: (2013)

Haematopoietic stem cells: past, present and future
por: Ng, Ashley P, et al.
Publicado: (2017)

Haematopoietic stem cell transplantation in systemic sclerosis
por: Walker, Ulrich A, et al.
Publicado: (2018)

Haematopoietic stem cells: entropic landscapes of differentiation
por: Wiesner, K., et al.
Publicado: (2018)

Requirements for human haematopoietic stem/progenitor cells
por: Nan, Xue, et al.
Publicado: (2021)

Haematopoietic stem and progenitor cells from human pluripotent stem cells
por: Sugimura, Ryohichi, et al.
Publicado: (2017)

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
por: Kyriakis, John M
Publicado: (2003)

LKB1 and AMP-activated protein kinase: regulators of cell polarity
por: Nakano, Atsushi, et al.
Publicado: (2012)

LKB1 and AMPK differentially regulate pancreatic β-cell identity
por: Kone, Marina, et al.
Publicado: (2014)

Homeostatic control of metabolic and functional fitness of T(reg) cells by LKB1 signaling
por: Yang, Kai, et al.
Publicado: (2017)

Cyp2aa9 regulates haematopoietic stem cell development in zebrafish
por: Chen, Jingying, et al.
Publicado: (2016)

Paracrine effects of haematopoietic cells on human mesenchymal stem cells
por: Zhou, Shuanhu
Publicado: (2015)

Arteriolar niches maintain haematopoietic stem cell quiescence
por: Kunisaki, Yuya, et al.
Publicado: (2013)

Autologous haematopoietic stem cell transplantation for neurological diseases
por: Burman, Joachim, et al.
Publicado: (2018)

Thrombotic microangiopathy following haematopoietic stem cell transplant
por: Seaby, Eleanor G., et al.
Publicado: (2017)

Haematopoietic Stem Cell Transplantation for Primary Haemophagocytic Lymphohistiocytosis
por: Lehmberg, Kai, et al.
Publicado: (2019)

Immunological barriers to haematopoietic stem cell gene therapy
por: Charlesworth, Carsten T., et al.
Publicado: (2022)

Noninfectious pulmonary complications of haematopoietic stem cell transplantation
por: Haider, Samran, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pe80itfg3n6kf33n96ageqcooa