A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing

We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical,...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishiguro, Kei-ichiro, Kim, Jihye, Fujiyama-Nakamura, Sally, Kato, Shigeaki, Watanabe, Yoshinori
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059921/
https://www.ncbi.nlm.nih.gov/pubmed/21274006
http://dx.doi.org/10.1038/embor.2011.2
_version_ 1782200460866748416
author Ishiguro, Kei-ichiro
Kim, Jihye
Fujiyama-Nakamura, Sally
Kato, Shigeaki
Watanabe, Yoshinori
author_facet Ishiguro, Kei-ichiro
Kim, Jihye
Fujiyama-Nakamura, Sally
Kato, Shigeaki
Watanabe, Yoshinori
author_sort Ishiguro, Kei-ichiro
collection PubMed
description We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.
format Text
id pubmed-3059921
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-30599212011-05-13 A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing Ishiguro, Kei-ichiro Kim, Jihye Fujiyama-Nakamura, Sally Kato, Shigeaki Watanabe, Yoshinori EMBO Rep Scientific Reports We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway. Nature Publishing Group 2011-03-03 2011-01-28 /pmc/articles/PMC3059921/ /pubmed/21274006 http://dx.doi.org/10.1038/embor.2011.2 Text en Copyright © 2011, European Molecular Biology Organization http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Scientific Reports
Ishiguro, Kei-ichiro
Kim, Jihye
Fujiyama-Nakamura, Sally
Kato, Shigeaki
Watanabe, Yoshinori
A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title_full A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title_fullStr A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title_full_unstemmed A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title_short A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
title_sort new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing
topic Scientific Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059921/
https://www.ncbi.nlm.nih.gov/pubmed/21274006
http://dx.doi.org/10.1038/embor.2011.2
work_keys_str_mv AT ishigurokeiichiro anewmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT kimjihye anewmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT fujiyamanakamurasally anewmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT katoshigeaki anewmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT watanabeyoshinori anewmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT ishigurokeiichiro newmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT kimjihye newmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT fujiyamanakamurasally newmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT katoshigeaki newmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing
AT watanabeyoshinori newmeiosisspecificcohesincompleximplicatedinthecohesincodeforhomologouspairing

Ejemplares similares