Immunocytochemical Localization of Claudin-1 in the Maturation Ameloblasts of Rat Incisors

Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RA...

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Detalles Bibliográficos
Autores principales: Nishikawa, Sumio, Abe, Michio
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059967/
https://www.ncbi.nlm.nih.gov/pubmed/21423390
http://dx.doi.org/10.3389/fphys.2010.00150
Descripción
Sumario:Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive with anti-claudin-1 antibodies. Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the presence of claudin-1 in the Golgi cisterns may indicate the presence of tight junction precursors before transportation to the junctional area.

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