Cargando…

RDX Binds to the GABA(A) Receptor–Convulsant Site and Blocks GABA(A) Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures

BACKGROUND: Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high-energy, trinitrated cyclic compound that has been used worldwide since World War II as an explosive in both military and civilian applications. RDX can be released in the environment by way of waste streams generated during the manu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Larry R., Aroniadou-Anderjaska, Vassiliki, Qashu, Felicia, Finne, Huckelberry, Pidoplichko, Volodymyr, Bannon, Desmond I., Braga, Maria F. M.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059999/ https://www.ncbi.nlm.nih.gov/pubmed/21362589 http://dx.doi.org/10.1289/ehp.1002588

Ejemplares similares

Erratum: Williams et al. “RDX Binds to the GABA(A) Receptor–Convulsant Site and Blocks GABA(A) Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures” [119:357–363 (2011)]
Publicado: (2013)

The seizure‐inducing plastic explosive RDX inhibits the α1β2γ2 GABA(A) receptor
por: Pressly, Brandon, et al.
Publicado: (2022)

Repeated Isoflurane Exposures Impair Long-Term Potentiation and Increase Basal GABAergic Activity in the Basolateral Amygdala
por: Long II, Robert P., et al.
Publicado: (2016)

RDX and miRNA Expression in B6C3F1 Mice
por: Bannon, Desmond I., et al.
Publicado: (2009)

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus
por: Figueiredo, Taiza H., et al.
Publicado: (2022)

Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition
por: Aroniadou-Anderjaska, Vassiliki, et al.
Publicado: (2023)

Microstructural and Sensitivity Changes of Neat, Spray-Dried RDX
por: Tisdale, Jeremy T., et al.
Publicado: (2022)

NQR Characteristics of an RDX Plastic Explosives Simulant
por: Turecek, J., et al.
Publicado: (2012)

Preparation and Characterization of Cyclotrimethylenetrinitramine (RDX) with Reduced Sensitivity
por: Wang, Yuqiao, et al.
Publicado: (2017)

RDX and miRNA Expression: Zhang and Pan Respond
por: Zhang, Baohong, et al.
Publicado: (2009)

Sub-Nanogram Detection of RDX Explosive by Monoclonal Antibodies
por: Ulaeto, David O., et al.
Publicado: (2015)

Ultraviolet Laser-induced ignition of RDX single crystal
por: Yan, Zhonghua, et al.
Publicado: (2016)

Multiple stressors in multiple species: Effects of different RDX soil concentrations and differential water-resourcing on RDX fate, plant health, and plant survival
por: Lance, Richard F., et al.
Publicado: (2020)

Metagenomic Insights into the RDX-Degrading Potential of the Ovine Rumen Microbiome
por: Li, Robert W., et al.
Publicado: (2014)

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice
por: Davidson, James P., et al.
Publicado: (2017)

The recovery of touch DNA from RDX-C4 evidences
por: Al-Snan, Noora R.
Publicado: (2020)

Molecular Dynamics Study on the Reaction of RDX Molecule with Si Substrate
por: Xu, Wei-Sen, et al.
Publicado: (2023)

Internal Explosion Performance of RDX@Nano-B Composite Explosives
por: Xi, Peng, et al.
Publicado: (2023)

Molecular Dynamics Simulations of the Thermal Decomposition of RDX/HTPB Explosives
por: Wu, Junying, et al.
Publicado: (2023)

RDX Induces Aberrant Expression of MicroRNAs in Mouse Brain and Liver
por: Zhang, Baohong, et al.
Publicado: (2009)

Biostimulation and microbial community profiling reveal insights on RDX transformation in groundwater
por: Wang, Dongping, et al.
Publicado: (2016)

Effects of Nano Aluminum Powder on the Mechanical Sensitivity of RDX-Based Explosives
por: Dong, Jun, et al.
Publicado: (2021)

The Effect of High-Quality RDX on the Safety and Mechanical Properties of Pressed PBX
por: Chen, Shixiong, et al.
Publicado: (2022)

RdxA Diversity and Mutations Associated with Metronidazole Resistance of Helicobacter pylori
por: Gong, Yanan, et al.
Publicado: (2023)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

Transcriptomic analysis of RDX and TNT interactive sublethal effects in the earthworm Eisenia fetida
por: Gong, Ping, et al.
Publicado: (2008)

The mutation of the rdxA gene in metronidazole-resistant Helicobacter pylori clinical isolates
por: Mirzaei, Nasrin, et al.
Publicado: (2014)

Carbon dioxide binary crystals via the thermal decomposition of RDX at high pressure
por: Connor, L. E., et al.
Publicado: (2017)

Experimental Study of Pyrolysis and Laser Ignition of Low-Vulnerability Propellants Based on RDX
por: Ehrhardt, Jordan, et al.
Publicado: (2020)

Mechanochemical fabrication and properties of CL-20/RDX nano co/mixed crystals
por: Song, Xiaolan, et al.
Publicado: (2018)

Effects of Perchlorate and Other Groundwater Inorganic Co-Contaminants on Aerobic RDX Degradation
por: Yadav, Amit, et al.
Publicado: (2022)

The potential role of astroglial GABA(A) receptors in autoimmune encephalitis associated with GABA(A) receptor antibodies and seizures
por: Ismail, Fatme Seval, et al.
Publicado: (2023)

Transition to absence seizures and the role of GABA(A) receptors
por: Crunelli, Vincenzo, et al.
Publicado: (2011)

Autosomal Recessive Nonsyndromic Hearing Impairment due to a Novel Deletion in the RDX Gene
por: Lee, Kwanghyuk, et al.
Publicado: (2011)

Trace Detection of RDX, HMX and PETN Explosives Using a Fluorescence Spot Sensor
por: Wang, Chen, et al.
Publicado: (2016)

Ab Initio Calculations of the N-N Bond Dissociation for the Gas-phase RDX and HMX
por: Liu, Lin-lin, et al.
Publicado: (2017)

Improving the Chemical Selectivity of an Electronic Nose to TNT, DNT and RDX Using Machine Learning
por: Gradišek, Anton, et al.
Publicado: (2019)

The Hh pathway promotes cell apoptosis through Ci-Rdx-Diap1 axis
por: Liu, Bin, et al.
Publicado: (2021)

Simultaneous Determination of RDX and HMX in Rat Plasma by LC-MS/MS and its Applications
por: Zhang, Xi, et al.
Publicado: (2022)

Shock response of condensed-phase RDX: molecular dynamics simulations in conjunction with the MSST method
por: Ge, Ni-Na, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dnqiir2i1udl0j60sndhdlpvsa