Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity

BACKGROUND: Quantitative high-throughput screening (qHTS) assays are increasingly being used to inform chemical hazard identification. Hundreds of chemicals have been tested in dozens of cell lines across extensive concentration ranges by the National Toxicology Program in collaboration with the Nat...

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Detalles Bibliográficos
Autores principales: Sedykh, Alexander, Zhu, Hao, Tang, Hao, Zhang, Liying, Richard, Ann, Rusyn, Ivan, Tropsha, Alexander
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060000/
https://www.ncbi.nlm.nih.gov/pubmed/20980217
http://dx.doi.org/10.1289/ehp.1002476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060000/
https://www.ncbi.nlm.nih.gov/pubmed/20980217
http://dx.doi.org/10.1289/ehp.1002476

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