Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

Somatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae diploid cells produce daughters without mitochondrial DNA, leading to loss of respiration competence and increased loss of heterozygosity (LOH)...

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Detalles Bibliográficos
Autores principales: Lindstrom, Derek L., Leverich, Christina K., Henderson, Kiersten A., Gottschling, Daniel E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060066/
https://www.ncbi.nlm.nih.gov/pubmed/21436897
http://dx.doi.org/10.1371/journal.pgen.1002015

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