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A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wi...
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060072/ https://www.ncbi.nlm.nih.gov/pubmed/21437268 http://dx.doi.org/10.1371/journal.pgen.1001333 |
| _version_ | 1782200487354826752 |
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| author | McKay, James D. Truong, Therese Gaborieau, Valerie Chabrier, Amelie Chuang, Shu-Chun Byrnes, Graham Zaridze, David Shangina, Oxana Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Rudnai, Peter Fabianova, Eleonora Bucur, Alexandru Bencko, Vladimir Holcatova, Ivana Janout, Vladimir Foretova, Lenka Lagiou, Pagona Trichopoulos, Dimitrios Benhamou, Simone Bouchardy, Christine Ahrens, Wolfgang Merletti, Franco Richiardi, Lorenzo Talamini, Renato Barzan, Luigi Kjaerheim, Kristina Macfarlane, Gary J. Macfarlane, Tatiana V. Simonato, Lorenzo Canova, Cristina Agudo, Antonio Castellsagué, Xavier Lowry, Ray Conway, David I. McKinney, Patricia A. Healy, Claire M. Toner, Mary E. Znaor, Ariana Curado, Maria Paula Koifman, Sergio Menezes, Ana Wünsch-Filho, Victor Neto, José Eluf Garrote, Leticia Fernández Boccia, Stefania Cadoni, Gabriella Arzani, Dario Olshan, Andrew F. Weissler, Mark C. Funkhouser, William K. Luo, Jingchun Lubiński, Jan Trubicka, Joanna Lener, Marcin Oszutowska, Dorota Schwartz, Stephen M. Chen, Chu Fish, Sherianne Doody, David R. Muscat, Joshua E. Lazarus, Philip Gallagher, Carla J. Chang, Shen-Chih Zhang, Zuo-Feng Wei, Qingyi Sturgis, Erich M. Wang, Li-E Franceschi, Silvia Herrero, Rolando Kelsey, Karl T. McClean, Michael D. Marsit, Carmen J. Nelson, Heather H. Romkes, Marjorie Buch, Shama Nukui, Tomoko Zhong, Shilong Lacko, Martin Manni, Johannes J. Peters, Wilbert H. M. Hung, Rayjean J. McLaughlin, John Vatten, Lars Njølstad, Inger Goodman, Gary E. Field, John K. Liloglou, Triantafillos Vineis, Paolo Clavel-Chapelon, Francoise Palli, Domenico Tumino, Rosario Krogh, Vittorio Panico, Salvatore González, Carlos A. Quirós, J. Ramón Martínez, Carmen Navarro, Carmen Ardanaz, Eva Larrañaga, Nerea Khaw, Kay-Tee Key, Timothy Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Trichopoulou, Antonia Linseisen, Jakob Boeing, Heiner Hallmans, Göran Overvad, Kim Tjønneland, Anne Kumle, Merethe Riboli, Elio Välk, Kristjan Voodern, Tõnu Metspalu, Andres Zelenika, Diana Boland, Anne Delepine, Marc Foglio, Mario Lechner, Doris Blanché, Hélène Gut, Ivo G. Galan, Pilar Heath, Simon Hashibe, Mia Hayes, Richard B. Boffetta, Paolo Lathrop, Mark Brennan, Paul |
| author_facet | McKay, James D. Truong, Therese Gaborieau, Valerie Chabrier, Amelie Chuang, Shu-Chun Byrnes, Graham Zaridze, David Shangina, Oxana Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Rudnai, Peter Fabianova, Eleonora Bucur, Alexandru Bencko, Vladimir Holcatova, Ivana Janout, Vladimir Foretova, Lenka Lagiou, Pagona Trichopoulos, Dimitrios Benhamou, Simone Bouchardy, Christine Ahrens, Wolfgang Merletti, Franco Richiardi, Lorenzo Talamini, Renato Barzan, Luigi Kjaerheim, Kristina Macfarlane, Gary J. Macfarlane, Tatiana V. Simonato, Lorenzo Canova, Cristina Agudo, Antonio Castellsagué, Xavier Lowry, Ray Conway, David I. McKinney, Patricia A. Healy, Claire M. Toner, Mary E. Znaor, Ariana Curado, Maria Paula Koifman, Sergio Menezes, Ana Wünsch-Filho, Victor Neto, José Eluf Garrote, Leticia Fernández Boccia, Stefania Cadoni, Gabriella Arzani, Dario Olshan, Andrew F. Weissler, Mark C. Funkhouser, William K. Luo, Jingchun Lubiński, Jan Trubicka, Joanna Lener, Marcin Oszutowska, Dorota Schwartz, Stephen M. Chen, Chu Fish, Sherianne Doody, David R. Muscat, Joshua E. Lazarus, Philip Gallagher, Carla J. Chang, Shen-Chih Zhang, Zuo-Feng Wei, Qingyi Sturgis, Erich M. Wang, Li-E Franceschi, Silvia Herrero, Rolando Kelsey, Karl T. McClean, Michael D. Marsit, Carmen J. Nelson, Heather H. Romkes, Marjorie Buch, Shama Nukui, Tomoko Zhong, Shilong Lacko, Martin Manni, Johannes J. Peters, Wilbert H. M. Hung, Rayjean J. McLaughlin, John Vatten, Lars Njølstad, Inger Goodman, Gary E. Field, John K. Liloglou, Triantafillos Vineis, Paolo Clavel-Chapelon, Francoise Palli, Domenico Tumino, Rosario Krogh, Vittorio Panico, Salvatore González, Carlos A. Quirós, J. Ramón Martínez, Carmen Navarro, Carmen Ardanaz, Eva Larrañaga, Nerea Khaw, Kay-Tee Key, Timothy Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Trichopoulou, Antonia Linseisen, Jakob Boeing, Heiner Hallmans, Göran Overvad, Kim Tjønneland, Anne Kumle, Merethe Riboli, Elio Välk, Kristjan Voodern, Tõnu Metspalu, Andres Zelenika, Diana Boland, Anne Delepine, Marc Foglio, Mario Lechner, Doris Blanché, Hélène Gut, Ivo G. Galan, Pilar Heath, Simon Hashibe, Mia Hayes, Richard B. Boffetta, Paolo Lathrop, Mark Brennan, Paul |
| author_sort | McKay, James D. |
| collection | PubMed |
| description | Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10(−7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10(−8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10(−8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10(−8); rs1229984-ADH1B, p = 7×10(−9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility. |
| format | Text |
| id | pubmed-3060072 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30600722011-03-23 A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium McKay, James D. Truong, Therese Gaborieau, Valerie Chabrier, Amelie Chuang, Shu-Chun Byrnes, Graham Zaridze, David Shangina, Oxana Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Rudnai, Peter Fabianova, Eleonora Bucur, Alexandru Bencko, Vladimir Holcatova, Ivana Janout, Vladimir Foretova, Lenka Lagiou, Pagona Trichopoulos, Dimitrios Benhamou, Simone Bouchardy, Christine Ahrens, Wolfgang Merletti, Franco Richiardi, Lorenzo Talamini, Renato Barzan, Luigi Kjaerheim, Kristina Macfarlane, Gary J. Macfarlane, Tatiana V. Simonato, Lorenzo Canova, Cristina Agudo, Antonio Castellsagué, Xavier Lowry, Ray Conway, David I. McKinney, Patricia A. Healy, Claire M. Toner, Mary E. Znaor, Ariana Curado, Maria Paula Koifman, Sergio Menezes, Ana Wünsch-Filho, Victor Neto, José Eluf Garrote, Leticia Fernández Boccia, Stefania Cadoni, Gabriella Arzani, Dario Olshan, Andrew F. Weissler, Mark C. Funkhouser, William K. Luo, Jingchun Lubiński, Jan Trubicka, Joanna Lener, Marcin Oszutowska, Dorota Schwartz, Stephen M. Chen, Chu Fish, Sherianne Doody, David R. Muscat, Joshua E. Lazarus, Philip Gallagher, Carla J. Chang, Shen-Chih Zhang, Zuo-Feng Wei, Qingyi Sturgis, Erich M. Wang, Li-E Franceschi, Silvia Herrero, Rolando Kelsey, Karl T. McClean, Michael D. Marsit, Carmen J. Nelson, Heather H. Romkes, Marjorie Buch, Shama Nukui, Tomoko Zhong, Shilong Lacko, Martin Manni, Johannes J. Peters, Wilbert H. M. Hung, Rayjean J. McLaughlin, John Vatten, Lars Njølstad, Inger Goodman, Gary E. Field, John K. Liloglou, Triantafillos Vineis, Paolo Clavel-Chapelon, Francoise Palli, Domenico Tumino, Rosario Krogh, Vittorio Panico, Salvatore González, Carlos A. Quirós, J. Ramón Martínez, Carmen Navarro, Carmen Ardanaz, Eva Larrañaga, Nerea Khaw, Kay-Tee Key, Timothy Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Trichopoulou, Antonia Linseisen, Jakob Boeing, Heiner Hallmans, Göran Overvad, Kim Tjønneland, Anne Kumle, Merethe Riboli, Elio Välk, Kristjan Voodern, Tõnu Metspalu, Andres Zelenika, Diana Boland, Anne Delepine, Marc Foglio, Mario Lechner, Doris Blanché, Hélène Gut, Ivo G. Galan, Pilar Heath, Simon Hashibe, Mia Hayes, Richard B. Boffetta, Paolo Lathrop, Mark Brennan, Paul PLoS Genet Research Article Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10(−7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10(−8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10(−8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10(−8); rs1229984-ADH1B, p = 7×10(−9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility. Public Library of Science 2011-03-17 /pmc/articles/PMC3060072/ /pubmed/21437268 http://dx.doi.org/10.1371/journal.pgen.1001333 Text en McKay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Research Article McKay, James D. Truong, Therese Gaborieau, Valerie Chabrier, Amelie Chuang, Shu-Chun Byrnes, Graham Zaridze, David Shangina, Oxana Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Rudnai, Peter Fabianova, Eleonora Bucur, Alexandru Bencko, Vladimir Holcatova, Ivana Janout, Vladimir Foretova, Lenka Lagiou, Pagona Trichopoulos, Dimitrios Benhamou, Simone Bouchardy, Christine Ahrens, Wolfgang Merletti, Franco Richiardi, Lorenzo Talamini, Renato Barzan, Luigi Kjaerheim, Kristina Macfarlane, Gary J. Macfarlane, Tatiana V. Simonato, Lorenzo Canova, Cristina Agudo, Antonio Castellsagué, Xavier Lowry, Ray Conway, David I. McKinney, Patricia A. Healy, Claire M. Toner, Mary E. Znaor, Ariana Curado, Maria Paula Koifman, Sergio Menezes, Ana Wünsch-Filho, Victor Neto, José Eluf Garrote, Leticia Fernández Boccia, Stefania Cadoni, Gabriella Arzani, Dario Olshan, Andrew F. Weissler, Mark C. Funkhouser, William K. Luo, Jingchun Lubiński, Jan Trubicka, Joanna Lener, Marcin Oszutowska, Dorota Schwartz, Stephen M. Chen, Chu Fish, Sherianne Doody, David R. Muscat, Joshua E. Lazarus, Philip Gallagher, Carla J. Chang, Shen-Chih Zhang, Zuo-Feng Wei, Qingyi Sturgis, Erich M. Wang, Li-E Franceschi, Silvia Herrero, Rolando Kelsey, Karl T. McClean, Michael D. Marsit, Carmen J. Nelson, Heather H. Romkes, Marjorie Buch, Shama Nukui, Tomoko Zhong, Shilong Lacko, Martin Manni, Johannes J. Peters, Wilbert H. M. Hung, Rayjean J. McLaughlin, John Vatten, Lars Njølstad, Inger Goodman, Gary E. Field, John K. Liloglou, Triantafillos Vineis, Paolo Clavel-Chapelon, Francoise Palli, Domenico Tumino, Rosario Krogh, Vittorio Panico, Salvatore González, Carlos A. Quirós, J. Ramón Martínez, Carmen Navarro, Carmen Ardanaz, Eva Larrañaga, Nerea Khaw, Kay-Tee Key, Timothy Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Trichopoulou, Antonia Linseisen, Jakob Boeing, Heiner Hallmans, Göran Overvad, Kim Tjønneland, Anne Kumle, Merethe Riboli, Elio Välk, Kristjan Voodern, Tõnu Metspalu, Andres Zelenika, Diana Boland, Anne Delepine, Marc Foglio, Mario Lechner, Doris Blanché, Hélène Gut, Ivo G. Galan, Pilar Heath, Simon Hashibe, Mia Hayes, Richard B. Boffetta, Paolo Lathrop, Mark Brennan, Paul A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title_full | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title_fullStr | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title_full_unstemmed | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title_short | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
| title_sort | genome-wide association study of upper aerodigestive tract cancers conducted within the inhance consortium |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060072/ https://www.ncbi.nlm.nih.gov/pubmed/21437268 http://dx.doi.org/10.1371/journal.pgen.1001333 |
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