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TCR Affinity for Self-Ligands Influences the Development and Function of Encephalitogenic T Cells

The specificity and affinity of self-reactive T cells is likely to impact the development of autoimmune-disease causing T cells in the thymus as well as their function in the periphery. We identified a naturally occurring, low affinity variant of an MBP Ac1-11/I-A(u) specific TCR that is known to in...

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Detalles Bibliográficos
Autores principales:	Li, Jianwei, Vandal, Omar, Sant'Angelo, Derek B.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060088/ https://www.ncbi.nlm.nih.gov/pubmed/21437282 http://dx.doi.org/10.1371/journal.pone.0017702

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