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Virulence of H5N1 virus in mice attenuates after in vitro serial passages

The virulence of A/Vietnam/1194/2004 (VN1194) in mice attenuated after serial passages in MDCK cells and chicken embryos, because the enriched large-plaque variants of the virus had significantly reduced virulence. In contrast, the small-plaque variants of the virus and the variants isolated from th...

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Detalles Bibliográficos
Autores principales:	Li, Jing, Liu, Bohua, Chang, Guohui, Hu, Yi, Zhan, Dawei, Xia, Yukun, Li, Yongqiang, Yang, Yinhui, Zhu, Qingyu
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060145/ https://www.ncbi.nlm.nih.gov/pubmed/21371335 http://dx.doi.org/10.1186/1743-422X-8-93

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